BIOMAT Database Logo BIOMAT Database Logo

Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles. 2004

Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.

UI MeSH Term Description Entries
D010069 Oxadiazoles Compounds containing five-membered heteroaromatic rings containing two carbons, two nitrogens, and one oxygen atom which exist in various regioisomeric forms. Oxadiazole
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D000927 Anticonvulsants Drugs used to prevent SEIZURES or reduce their severity. Anticonvulsant,Anticonvulsant Drug,Anticonvulsive Agent,Anticonvulsive Drug,Antiepileptic,Antiepileptic Agent,Antiepileptic Agents,Antiepileptic Drug,Anticonvulsant Drugs,Anticonvulsive Agents,Anticonvulsive Drugs,Antiepileptic Drugs,Antiepileptics,Agent, Anticonvulsive,Agent, Antiepileptic,Agents, Anticonvulsive,Agents, Antiepileptic,Drug, Anticonvulsant,Drug, Anticonvulsive,Drug, Antiepileptic,Drugs, Anticonvulsant,Drugs, Anticonvulsive,Drugs, Antiepileptic
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular

Related Publications

Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Synthesis and anticonvulsant activity of new 2-substituted-5-(2-benzyloxyphenyl)-1,3,4-oxadiazoles.
April 2005, Bioorganic & medicinal chemistry letters,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Design and synthesis of new 2-substituted-5-[2-(2-halobenzyloxy)phenyl]-1,3,4-oxadiazoles as anticonvulsant agents.
April 2008, Chemical & pharmaceutical bulletin,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Synthesis and antimicrobial activity of new 5-(2-thienyl)-1,2,4-triazoles and 5-(2-thienyl)-1,3,4-oxadiazoles and related derivatives.
January 2010, Molecules (Basel, Switzerland),
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Synthesis and antimicrobial activity of pyrimidinyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
February 2018, European journal of medicinal chemistry,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
[Synthesis and anticonvulsive activity of some new bisubstituted 1,3,4-oxadiazoles and 1H-1,2,4-triazoles].
January 1989, Annales pharmaceutiques francaises,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Synthesis and antimicrobial activity of pyrrolyl/pyrazolyl arylaminosulfonylmethyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
January 2011, Chemical & pharmaceutical bulletin,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Synthesis, antimicrobial and cytotoxic activities of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazoles.
May 2009, European journal of medicinal chemistry,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Synthesis and anticancer evaluation of 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, 1,2,4-triazoles and Mannich bases.
January 2015, Chemical & pharmaceutical bulletin,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
15N NMR study of substituted 2-(phenylamino)-5-phenyl-1,3,4-oxadiazoles.
February 2007, Magnetic resonance in chemistry : MRC,
Ali Almasirad, and Sayyed A Tabatabai, and Mehrdad Faizi, and Abbas Kebriaeezadeh, and Nazila Mehrabi, and Afshin Dalvandi, and Abbas Shafiee
Synthesis, characterization and antibacterial activity of 2-[1-(5-chloro-2-methoxy-phenyl)-5-methyl-1H-pyrazol-4-yl]-5-(substituted-phenyl)-[1,3,4]oxadiazoles.
November 2009, European journal of medicinal chemistry,
Copied contents to your clipboard!