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We have analyzed cultures of malignant lymphoma cells and cells from patients with acute lymphoid leukemia in methylcellulose for their ability to from colonies. Clonogenic growth was examined in the presence or absence of fetal calf serum (FCS), platelet-poor plasma (PPP), medium conditioned by phytohemagglutinin-stimulated leukocytes (PHA-LCM), or irradiated allogeneic bone marrow stroma cells. Cells from 25 lymphoma patients--17 with non-Hodgkin's lymphoma (NHL), eight with Hodgkin's disease (HD)--and from 19 patients with acute lymphocytic leukemia (ALL) were investigated. We show that colony growth can be obtained in a minority of cases (in 3 NHL, 5 HD, and 2 ALL) and that the use of FCS and allogeneic irradiated stroma cells may be required for optimal colony formation.
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
January 1995,
Journal of cancer research and clinical oncology,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
January 1977,
Haematology and blood transfusion,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
November 2012,
Nihon rinsho. Japanese journal of clinical medicine,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
March 1986,
Cancer research,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
August 2007,
Zhongguo shi yan xue ye xue za zhi,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
August 1972,
Journal of the National Cancer Institute,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
October 1988,
Bulletin de l'Academie nationale de medecine,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
January 1983,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
May 1987,
Virology,
E S Strobel, and
K J Bross, and
R Mertelsmann, and
F Herrmann
January 1987,
Nouvelle revue francaise d'hematologie,
