Expression of the sodium-driven chloride bicarbonate exchanger NCBE during prenatal mouse development. 2004

C A Hübner, and M Hentschke, and S Jacobs, and I Hermans-Borgmeyer
Institute of Human Genetics, University Hospital Eppendorf, Butenfeld 42, D-22529 Hamburg, Germany. c.huebner@uke.uni-hamburg.de

In the immature central nervous system (CNS) GABA-mediated excitation is thought to be an important developmental signal. It depends on a high intracellular chloride concentration ([Cl(-)](i)) of the particular neuron. [Cl(-)](i) is a consequence of chloride transport processes across the plasma membrane. The ongoing expression of the KCl-co-transporter KCC2 eventually lowers [Cl(-)](i) in most CNS neurons and thus renders GABA hyperpolarizing. As NCBE, a sodium-dependent chloride-bicarbonate exchanger, also lowers [Cl(-)](i) and may thus modulate the GABA-response, we analyzed its expression during prenatal mouse development before establishment of the mature KCC2 expression. Indeed, NCBE is expressed very early in CNS neurons and precedes the expression of KCC2. Unlike KCC2, NCBE is expressed in the peripheral nervous system and in non-neuronal tissues as the choroid plexus, the dura, and some epithelia including the acid secreting epithelium of the stomach and the duodenal epithelium.

UI MeSH Term Description Entries
D002490 Central Nervous System The main information-processing organs of the nervous system, consisting of the brain, spinal cord, and meninges. Cerebrospinal Axis,Axi, Cerebrospinal,Axis, Cerebrospinal,Central Nervous Systems,Cerebrospinal Axi,Nervous System, Central,Nervous Systems, Central,Systems, Central Nervous
D000096922 K Cl- Cotransporters A subclass of symporters that specifically transport POTASSIUM and CHLORIDE ions across cellular membranes. Potassium chloride cotransporters play roles in regulating cell volume and intracellular chloride concentration. Electroneutral Potassium-Chloride Co-transporter 3,Electroneutral Potassium-Chloride Cotransporter 3,K Cl- Co-transporters,K(+), Cl(-)-Co-transporters,K(+), Cl(-)-Cotransporters,K-Cl Co-transporter,K-Cl Co-transporter 3,K-Cl Cotransporter,K-Cl Cotransporter 3,KCC2 Co-transporter,KCC2 Cotransporter,KCC3 Co-transporter,KCC3 Cotransporter,KCC4 Co-transporter,KCC4 Cotransporter,Potassium-Chloride Co-transporter 2,Potassium-Chloride Co-transporter 4,Potassium-Chloride Co-transporters,Potassium-Chloride Cotransporter 2,Potassium-Chloride Cotransporter 4,Potassium-Chloride Cotransporters,Potassium-Chloride Symporters,SLC12A5 Protein,SLC12A6 Protein,SLC12A7 Protein,Solute Carrier Family 12 Member 5,Solute Carrier Family 12 Member 6,Solute carrier family 12 member 7,Cl- Co-transporters, K,Co-transporter 2, Potassium-Chloride,Co-transporter 3, K-Cl,Co-transporter 4, Potassium-Chloride,Co-transporter, K-Cl,Co-transporter, KCC2,Co-transporter, KCC3,Co-transporter, KCC4,Co-transporters, K Cl-,Co-transporters, Potassium-Chloride,Cotransporter, K-Cl,Cotransporter, KCC2,Cotransporter, KCC3,Cotransporter, KCC4,Cotransporters, K Cl-,Cotransporters, Potassium-Chloride,Electroneutral Potassium Chloride Co transporter 3,Electroneutral Potassium Chloride Cotransporter 3,K Cl Co transporter,K Cl Co transporter 3,K Cl Co transporters,K Cl Cotransporter,K Cl Cotransporter 3,K Cl Cotransporters,KCC2 Co transporter,KCC3 Co transporter,KCC4 Co transporter,Potassium Chloride Co transporter 2,Potassium Chloride Co transporter 4,Potassium Chloride Co transporters,Potassium Chloride Cotransporter 2,Potassium Chloride Cotransporter 4,Potassium Chloride Cotransporters,Potassium Chloride Symporters,Protein, SLC12A5,Protein, SLC12A6,Protein, SLC12A7
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001345 Autoradiography The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed) Radioautography
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018507 Gene Expression Regulation, Developmental Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. Developmental Gene Expression Regulation,Embryologic Gene Expression Regulation,Gene Expression Regulation, Embryologic,Regulation of Gene Expression, Developmental,Regulation of Gene Expression, Embryologic,Regulation, Gene Expression, Developmental,Regulation, Gene Expression, Embryologic
D027963 Chloride-Bicarbonate Antiporters Electroneutral chloride bicarbonate exchangers that allow the exchange of BICARBONATE IONS exchange for CHLORIDE IONS across the cellular membrane. The action of specific antiporters in this class serve important functions such as allowing the efficient exchange of bicarbonate across red blood cell membranes as they passage through capillaries and the reabsorption of bicarbonate ions by the kidney. AE Proteins,AE2 Anion Exchanger,AE2 Chloride-Bicarbonate Exchanger,AE3 Anion Exchanger,AE4 Anion Exchanger,Anion Exchange Protein 2,Anion Exchange Protein 3,Anion Exchange Protein 4,Anion Exchanger 2,Anion Exchanger 3,Anion Exchanger 4,Bicarbonate-Chloride Antiport,Cardiac Brain Band 3-Like Protein,Chloride-Bicarbonate Exchanger,Chloride-Bicarbonate Exchangers,Cl(-)-HCO3(-)-Exchanger,Cl- HCO3- Exchanger,Cl- HCO3- Exchangers,Neuronal Band 3-Like Protein,Non-Erythroid Band 3-Like Protein,SLC4A2 Protein,SLC4A3 Protein,SLC4A9 Protein,Sodium Bicarbonate Cotransporter 5,Solute Carrier Family 4 Member 2,Solute Carrier Family 4 Member 3,Solute Carrier Family 4 Member 9,Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 9,AE2 Chloride Bicarbonate Exchanger,Anion Exchanger, AE2,Anion Exchanger, AE3,Anion Exchanger, AE4,Antiport, Bicarbonate-Chloride,Antiporters, Chloride-Bicarbonate,Bicarbonate Chloride Antiport,Cardiac Brain Band 3 Like Protein,Chloride Bicarbonate Antiporters,Chloride Bicarbonate Exchanger,Chloride Bicarbonate Exchangers,Chloride-Bicarbonate Exchanger, AE2,Cl HCO3 Exchanger,Cl HCO3 Exchangers,Exchanger, Chloride-Bicarbonate,Exchangers, Chloride-Bicarbonate,Exchangers, Cl- HCO3-,HCO3- Exchangers, Cl-,Neuronal Band 3 Like Protein,Non Erythroid Band 3 Like Protein,Protein, SLC4A2,Protein, SLC4A3,Protein, SLC4A9,Proteins, AE
D027981 Symporters Membrane transporters that co-transport two or more dissimilar molecules in the same direction across a membrane. Usually the transport of one ion or molecule is against its electrochemical gradient and is "powered" by the movement of another ion or molecule with its electrochemical gradient. Co-Transporter,Co-Transporters,Symporter,Co Transporter,Co Transporters

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