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Primary presentation of glioblastoma multiforme with leptomeningeal metastasis in the absence of previous craniotomy: a case report. 2004

Surjeet Pohar, and William Taylor, and Vishal S Chandan, and Hemangini Shah, and Robert H Sagerman
Department of Radiation Oncology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. pohars@upstate.edu

Glioblastoma multiforme is a highly malignant glioma with a well-known tendency for intracranial spread but rarely for extracranial spread. We report a case of an adult woman who presented with symptoms of leptomeningeal metastasis from an intracranial glioblastoma multiforme located adjacent to the lateral ventricle. There have been very few cases of glioblastoma multiforme presenting with leptomeningeal metastasis in the absence of previous therapeutic intervention.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002551 Cerebral Ventricle Neoplasms Neoplasms located in the brain ventricles, including the two lateral, the third, and the fourth ventricle. Ventricular tumors may be primary (e.g., CHOROID PLEXUS NEOPLASMS and GLIOMA, SUBEPENDYMAL), metastasize from distant organs, or occur as extensions of locally invasive tumors from adjacent brain structures. Intraventricular Neoplasms,Ventricular Neoplasms, Brain,Ventricular Tumors, Brain,Brain Ventricular Neoplasms,Cerebral Ventricle Tumors,Cerebroventricular Neoplasms,Neoplasms, Cerebral Ventricle,Neoplasms, Cerebroventricular,Neoplasms, Intraventricular,Neoplasms, Ventricular, Brain,Brain Ventricular Neoplasm,Brain Ventricular Tumor,Brain Ventricular Tumors,Cerebral Ventricle Neoplasm,Cerebral Ventricle Tumor,Cerebroventricular Neoplasm,Intraventricular Neoplasm,Neoplasm, Brain Ventricular,Neoplasm, Cerebral Ventricle,Neoplasm, Cerebroventricular,Neoplasm, Intraventricular,Neoplasms, Brain Ventricular,Tumor, Brain Ventricular,Tumor, Cerebral Ventricle,Tumors, Brain Ventricular,Tumors, Cerebral Ventricle,Ventricle Tumor, Cerebral,Ventricle Tumors, Cerebral,Ventricular Neoplasm, Brain,Ventricular Tumor, Brain
D005260 Female Females
D005909 Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. Astrocytoma, Grade IV,Giant Cell Glioblastoma,Glioblastoma Multiforme,Astrocytomas, Grade IV,Giant Cell Glioblastomas,Glioblastoma, Giant Cell,Glioblastomas,Glioblastomas, Giant Cell,Grade IV Astrocytoma,Grade IV Astrocytomas
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013120 Spinal Cord Neoplasms Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA. Intradural-Extramedullary Spinal Cord Neoplasms,Intramedullary Spinal Cord Neoplasms,Intramedullary Spinal Cord Neoplasms, Primary,Neoplasms, Spinal Cord,Primary Intramedullary Spinal Cord Neoplasms,Primary Spinal Cord Neoplasms, Intramedullary,Spinal Cord Neoplasms, Benign,Spinal Cord Neoplasms, Intradural-Extramedullary,Spinal Cord Neoplasms, Intramedullary,Spinal Cord Neoplasms, Malignant,Spinal Cord Neoplasms, Primary Intramedullary,Tumors, Spinal Cord,Intradural Extramedullary Spinal Cord Neoplasms,Neoplasm, Spinal Cord,Spinal Cord Neoplasm,Spinal Cord Neoplasms, Intradural Extramedullary,Spinal Cord Tumor,Spinal Cord Tumors,Tumor, Spinal Cord
D017809 Fatal Outcome Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept. Fatal Outcomes,Outcome, Fatal,Outcomes, Fatal

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