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Vogt-Koyanagi-Harada disease occurring during interferon alpha therapy for chronic hepatitis C. 2004
Akinori Kasahara, and
Atsushi Hiraide, and
Naruya Tomita, and
Hiromi Iwahashi, and
Akihisa Imagawa, and
Nobuyuki Ohguro, and
Shuji Yamamoto, and
Eiji Mita, and
Norio Hayashi
Department of General Medicine, Osaka University Graduate School of Medicine, 2-15 Yamada-Oka, 565-0871, Suita, Japan.
Retinal abnormalities, including retinal hemorrhage and "cotton-wool" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C. Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon. Therefore, we conclude that chronic hepatitis C patients, especially people with darkly pigmented skin, need to be closely monitored for ophthalmologic complications, by periodic check-up of the optic fundi, for a prolonged period, during interferon treatment.
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