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We report a simple and direct procedure for the measurement of circulating free testosterone concentrations by using saliva as a matrix rather than serum. There is a close correlation between saliva testosterone values measured by radioimmunoassay, calculated values of free testosterone, and free testosterone estimated by equilibrium dialysis. Our method is direct and has the advantage that the biologic fluid can be obtained routinely by noninvasive techniques outside the clinic during a course of therapy. We also show that a single saliva value is of greater diagnostic use than any of the currently used androgen assays. Testosterone was found to be elevated in the saliva of 17 infertility patients diagnosed as having polycystic ovarian syndrome, 14 of these patients were hirsute.
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
May 1993,
Annals of the New York Academy of Sciences,
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
February 1975,
American journal of obstetrics and gynecology,
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
March 2020,
The Journal of clinical endocrinology and metabolism,
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
October 2002,
Human reproduction (Oxford, England),
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
January 2012,
Endokrynologia Polska,
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
January 1985,
Clinical and experimental obstetrics & gynecology,
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
January 2022,
Frontiers in endocrinology,
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
September 2007,
Human reproduction (Oxford, England),
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
March 2007,
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics,
R G Smith, and
P K Besch, and
B Dill, and
V C Buttram
January 2004,
Psychosomatic medicine,
