Biomaterial Database

Regulation of branched chain amino acid metabolism in ruminants. 1992

I Papet, and J Grizard, and D Bonin, and M Arnal

Laboratoire d'Etude du Métabolisme Azoté, INRA-Theix, Ceyrat, France.

The regulation of branched-chain amino acid (BCAA) metabolism has been studied in ruminants mainly during the last decade. Evidences support that the rate of BCAA catabolism is lower in ruminants than in monogastrics. This is associated with a low specific BCAA aminotransferase (first catabolic enzyme) activity and a relatively low degree of activation of the second catabolic enzyme in post-natal ruminant tissues. Similarly to monogastrics in vivo BCAA catabolism involves an interorgan cooperation in ruminants. The benefic effect of leucine excess in protein turnover has also been raised. By contrast leucine excess does not stimulate the rate of isoleucine and valine catabolism in ruminants as much as in monogastrics.

UI	MeSH Term	Description	Entries
D009928	Organ Specificity	Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.	Tissue Specificity,Organ Specificities,Specificities, Organ,Specificities, Tissue,Specificity, Organ,Specificity, Tissue,Tissue Specificities
D011506	Proteins	Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.	Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D006706	Homeostasis	The processes whereby the internal environment of an organism tends to remain balanced and stable.	Autoregulation
D000597	Amino Acids, Branched-Chain	Amino acids which have a branched carbon chain.	Branched-Chain Amino Acid,Amino Acids, Branched Chain,Acid, Branched-Chain Amino,Acids, Branched-Chain Amino,Amino Acid, Branched-Chain,Branched Chain Amino Acid,Branched-Chain Amino Acids
D000637	Transaminases	A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.	Aminotransferase,Aminotransferases,Transaminase
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012418	Ruminants	A suborder of the order ARTIODACTYLA whose members have the distinguishing feature of a four-chambered stomach, including the capacious RUMEN. Horns or antlers are usually present, at least in males.	Goats, Mountain,Ruminantia,Oreamnos americanus,Goat, Mountain,Mountain Goat,Mountain Goats,Ruminant
D013045	Species Specificity	The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.	Species Specificities,Specificities, Species,Specificity, Species