Effect of haemodialysis on regional and transmural inhomogeneities of the ventricular repolarisation phase. 2005

Andrzej J Jaroszyński, and Wojciech T Załuska, and Andrzej Ksiazek
Chair and Clinic of Nephrology, Medical University of Lublin, Lublin, Poland. JaroszynskiAJ@interia.pl <JaroszynskiAJ@interia.pl>

Recent studies have indicated increased ventricular repolarisation dispersion in haemodialysis (HD) patients. The purpose of this study was to estimate the effect of the HD process on parameters of regional and transmyocardial repolarisation inhomogeneities. Thirty-two selected HD patients (without relevant diseases and medication known to affect the QT interval) were included. Dispersion of the QT corrected interval (QT-c-D) and the corrected interval between the peak and the end of the T wave (Tpe-c-D) were evaluated before and after HD, and in controls. Blood chemistry and extracellular body water (ECW) were evaluated before and after HD. Predialysis QT-c-D and Tpe-c-D were higher in patients (53.40 +/- 17.39 and 47.50 +/- 13.68 ms, respectively) than in controls (34.91 +/- 17.70 ms, p < 0.001 and 31.9 +/- 16.76 ms, p < 0.001, respectively). HD induced an increase in the QT-c-D (67.59 +/- 19.40 ms; p < 0.001) and Tpe-c-D (62.89 +/- 14.33 ms; p < 0.001). Stepwise multiple regression identified the independent risk factors of QT-c-D (the differences between pre- and postdialysis phosphorus, potassium and calcium levels and ECW values) and Tpe-c-D (the differences between pre- and postdialysis phosphorus levels, calcium levels and ECW values) increases, induced by the HD process. The HD process increases regional and transmyocardial repolarisation phase inhomogeneities in HD patients. Changes of phosphorus, calcium and potassium levels plus ECW values seem to be important predisposing factors as far as the increase in ventricular inhomogeneities in HD patients is concerned.

UI MeSH Term Description Entries
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010758 Phosphorus A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions. Black Phosphorus,Phosphorus-31,Red Phosphorus,White Phosphorus,Yellow Phosphorus,Phosphorus 31,Phosphorus, Black,Phosphorus, Red,Phosphorus, White,Phosphorus, Yellow
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D001834 Body Water Fluids composed mainly of water found within the body. Water, Body
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D004562 Electrocardiography Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY. 12-Lead ECG,12-Lead EKG,12-Lead Electrocardiography,Cardiography,ECG,EKG,Electrocardiogram,Electrocardiograph,12 Lead ECG,12 Lead EKG,12 Lead Electrocardiography,12-Lead ECGs,12-Lead EKGs,12-Lead Electrocardiographies,Cardiographies,ECG, 12-Lead,EKG, 12-Lead,Electrocardiograms,Electrocardiographies, 12-Lead,Electrocardiographs,Electrocardiography, 12-Lead
D005260 Female Females

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