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Synthesis of 5-alkynylated d4T analogues as potential HIV-1 reverse transcriptase inhibitors. 2004
A Ciurea, and
C Fossey, and
D Gavriliu, and
Z Delbederi, and
E Sugeac, and
D Laduree, and
S Schmidt, and
G Laumond, and
A M Aubertin
Centre d'Etudes et de Recherche sur le Médicament de Normandie, UFR des Sciences Pharmaceutiques, F-14032 Caen Cedex, France.
A series of 2',3'-didehydro-2',3'-dideoxynucleosides substituted with an alkynylhydroxy- (6, 7, 12 and 13) and alkynylamino- (20) groups at the C-5 position were synthesized. All these five target modified nucleosides were tested for anti-human immunodeficiency virus type 1 activity in CEM-SS and MT-4 cells and unfortunately displayed no improvement in antiviral activity.
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C Fossey, and
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D Laduree, and
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A M Aubertin
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Archiv der Pharmazie,
A Ciurea, and
C Fossey, and
D Gavriliu, and
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E Sugeac, and
D Laduree, and
S Schmidt, and
G Laumond, and
A M Aubertin
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A Ciurea, and
C Fossey, and
D Gavriliu, and
Z Delbederi, and
E Sugeac, and
D Laduree, and
S Schmidt, and
G Laumond, and
A M Aubertin
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Applied microbiology and biotechnology,
A Ciurea, and
C Fossey, and
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Z Delbederi, and
E Sugeac, and
D Laduree, and
S Schmidt, and
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Journal of medicinal chemistry,
