Until today little is known about the psychosomatic aspects of uveitis. The hypothesis that stressful life events are associated with the onset of diseases and that uveitis led to poor quality of life are discussed in the actual literature. Life events (Schedule of Recent Experiences), coping strategies (Coping Questionnaire; Essen Coping Questionnaire), psychological distress (Brief Symptom Inventory), and vision-specific quality of life (National Eye Institute Visual Functioning Questionnaire) of 51 patients with uveitis and 51 strict parallel controls were compared with another. The patients scored higher on the Schedule of Recent Experiences, lower regarding different coping strategies, and they demonstrated higher psychological distress (low effects), and they demonstrated lower disease-specific quality of life (high effect). In summary an unspecific stress hypothesis was supported; future directions of investigation were discussed.