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Efavirenz and nevirapine are frequently used drugs in antiretroviral therapy. Rashes are common side effects of these drugs. In this study, we examined the characteristics of efavirenz- and nevirapine-associated rashes. This prospective nonrandomized multicenter study included 662 HIV-infected patients (efavirenz: 325, nevirapine: 337) to determine incidence, duration, cross-reactivity, and outcome upon reexposure. Of the treated patients, 4.5% (n=30) developed rashes (nevirapine: 2.4% and efavirenz: 6.4%). In four patients treatment was not interrupted. Three patients were re-exposed to the initial drug without any side effects. Therapy with nevirapine or efavirenz does not have to be interrupted if rashes exhibit no blistering, mucosal manifestations, or systemic signs.
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
February 2002,
Sexually transmitted infections,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
January 2005,
Enfermedades infecciosas y microbiologia clinica,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
May 2004,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
June 2015,
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
June 2017,
The Pediatric infectious disease journal,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
February 2008,
Fundamental & clinical pharmacology,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
October 2004,
PLoS medicine,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
July 2007,
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
July 2000,
AIDS (London, England),
M Hartmann, and
J Brust, and
D Schuster, and
F Mosthaf, and
M Procaccianti, and
J A Rump, and
H Klinker, and
D Petzoldt
January 2010,
AIDS (London, England),
