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BACKGROUND Conflicting reports on the mechanism of action of ascorbic acid level in male reproductive system exist and very little is known about the ascorbic acid status in Nigerian males with weak fertility. METHODS Ascorbate that accumulates preferentially in the testis, the lipid and lipoprotein levels were determined in the plasma of Nigerian males. Twenty-seven (27) male with inadequate spermatogenesis (36+/-1.0) years, with mean value of 15.6+/-6.90 million/cm3 sperm count and fourteen (14) controls (34+/-0.6) years, with mean value of 108.0+/-25.42 million/cm3 sperm count were selected for this study. The anthropometric indices were also determined. RESULTS There were highly significant decreases in sperm cell count, percentage motility and percentage vitality (p<0.001) in each case, while percentage morphologically abnormal sperm cells was significantly elevated (p<0.001) compared with the control values. There were significant decreases in the seminal and plasma ascorbic acid concentrations (p<0.001) in the males who had inadequate spermatogenesis compared with the control values. The plasma total cholesterol (TC) and body mass index (BMI) were not significantly different from the corresponding control values, but the plasma low density lipoprotein (LDLC) (p<0.001) and triglyceride (TG)(p<0.01) concentrations were significantly increased in all the patients. While the plasma high density lipoprotein cholesterol (HDLC)(p<0.001) was significantly decreased compared with the controls. The plasma lipid and lipoprotein levels did not demonstrate any definite pattern with the sperm characteristics. CONCLUSIONS The decreased semen ascorbate level may play a significant role in the reduced sperm characteristics in these patients.
M O Ebesunun, and
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March 1971,
American journal of obstetrics and gynecology,
M O Ebesunun, and
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A A Onyeaghala
January 1982,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
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October 1979,
Fertility and sterility,
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October 1981,
Journal of tropical pediatrics,
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January 1987,
Annals of the New York Academy of Sciences,
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February 1974,
The American journal of clinical nutrition,
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A A Onyeaghala
July 1947,
Science (New York, N.Y.),
M O Ebesunun, and
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The Journal of endocrinology,
M O Ebesunun, and
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January 1969,
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