BIOMAT Database Logo BIOMAT Database Logo

Serum levels of advanced glycation end products are associated with in-stent restenosis in diabetic patients. 2005

Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.

The formation of advanced glycation end products (AGEs), in various tissues has been known to enhance immunoinflammatory reactions and local oxidant stresses in long standing diabetes. Recently, AGEs have been reported to play a role in neointimal formation in animal models of arterial injury. We attempted to determine whether the serum levels of AGEs are associated with coronary restenosis in diabetic patients. Blood samples were collected from diabetic patients with coronary artery disease undergoing stent implantation and the serum levels of AGEs were analyzed by the fluorescent intensity method. The development of in-stent restenosis (ISR) was evaluated by a 6-month follow-up coronary angiography. A total of 263 target lesions were evaluated, in 203 patients. The ISR rate in the high-AGE (>170 U/ml) group (40.1%) was significantly higher than in the low-AGE group (<or=170 U/ml) (19.6%) (p<0.001). Furthermore, multivariate analysis revealed that a high level of serum AGEs is an independent risk factor for the development of ISR (odds ratio, 2.659; 95% CI, 1.431-4.940; p=0.002). The serum levels of AGEs constitute an excellent predictive factor for ISR, and should be one of the guidelines for medical therapy and interventional strategy to prevent ISR in diabetic patients.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003324 Coronary Artery Disease Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause. Arteriosclerosis, Coronary,Atherosclerosis, Coronary,Coronary Arteriosclerosis,Coronary Atherosclerosis,Left Main Coronary Artery Disease,Left Main Coronary Disease,Left Main Disease,Arterioscleroses, Coronary,Artery Disease, Coronary,Artery Diseases, Coronary,Atheroscleroses, Coronary,Coronary Arterioscleroses,Coronary Artery Diseases,Coronary Atheroscleroses,Left Main Diseases
D003924 Diabetes Mellitus, Type 2 A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY. Diabetes Mellitus, Adult-Onset,Diabetes Mellitus, Ketosis-Resistant,Diabetes Mellitus, Maturity-Onset,Diabetes Mellitus, Non-Insulin-Dependent,Diabetes Mellitus, Slow-Onset,Diabetes Mellitus, Stable,MODY,Maturity-Onset Diabetes Mellitus,NIDDM,Diabetes Mellitus, Non Insulin Dependent,Diabetes Mellitus, Noninsulin Dependent,Diabetes Mellitus, Noninsulin-Dependent,Diabetes Mellitus, Type II,Maturity-Onset Diabetes,Noninsulin-Dependent Diabetes Mellitus,Type 2 Diabetes,Type 2 Diabetes Mellitus,Adult-Onset Diabetes Mellitus,Diabetes Mellitus, Adult Onset,Diabetes Mellitus, Ketosis Resistant,Diabetes Mellitus, Maturity Onset,Diabetes Mellitus, Slow Onset,Diabetes, Maturity-Onset,Diabetes, Type 2,Ketosis-Resistant Diabetes Mellitus,Maturity Onset Diabetes,Maturity Onset Diabetes Mellitus,Non-Insulin-Dependent Diabetes Mellitus,Noninsulin Dependent Diabetes Mellitus,Slow-Onset Diabetes Mellitus,Stable Diabetes Mellitus
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D015607 Stents Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting. Stent
D017127 Glycation End Products, Advanced A heterogeneous group of compounds derived from rearrangements, oxidation, and cross-linking reactions that follow from non-enzymatic glycation of amino groups in PROTEINS; LIPIDS; or NUCLEIC ACIDS. Their accumulation in vivo accelerates under hyperglycemic, oxidative, or inflammatory conditions. Heat also accelerates the formation of advanced glycation end products (AGEs) such seen with the browning of food during cooking. Advanced Glycation End Product,Advanced Glycation Endproduct,Advanced Maillard Reaction End Product,Glycated Lipids,Glycotoxins,Maillard Product,Maillard Reaction End Product,Maillard Reaction Product,Advanced Glycation End Products,Advanced Glycation Endproducts,Advanced Maillard Reaction End Products,Glycation Endproducts, Advanced,Maillard Products,Maillard Reaction End Products,Maillard Reaction Products,Glycation Endproduct, Advanced,Lipids, Glycated,Product, Maillard Reaction,Products, Maillard,Products, Maillard Reaction,Reaction Products, Maillard

Related Publications

Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Increased serum levels of advanced glycation end products in NIDDM patients with diabetic complications.
June 1998, Diabetes care,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
INCREASED DIETARY INTAKE AND SERUM LEVELS OF ADVANCED GLYCATION END PRODUCTS (AGES) ARE ASSOCIATED WITH DIABETIC MACULAR EDEMA.
January 2022, Acta endocrinologica (Bucharest, Romania : 2005),
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Advanced Glycation End Products:Receptors for Advanced Glycation End Products Axis in Coronary Stent Restenosis: A Prospective Study.
December 2018, The International journal of angiology : official publication of the International College of Angiology, Inc,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Increased serum levels of advanced glycation end-products and diabetic complications.
August 1998, Diabetes research and clinical practice,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Erratum to: Advanced Glycation End Products: Receptors for Advanced Glycation End Products Axis in Coronary Stent Restenosis: A Prospective Study.
December 2018, The International journal of angiology : official publication of the International College of Angiology, Inc,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Serum advanced glycation end products (AGEs) are associated with insulin resistance.
July 2011, Diabetes/metabolism research and reviews,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Serum advanced glycation end products are not associated with muscle strength in hemodialysis patients.
April 2019, European journal of clinical nutrition,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Serum levels of glucose-derived advanced glycation end products are associated with the severity of diabetic retinopathy in type 2 diabetic patients without renal dysfunction.
January 2002, International journal of clinical pharmacology research,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Increased serum advanced glycation end products are associated with impairment in HDL antioxidative capacity in diabetic nephropathy.
August 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Eui-Young Choi, and Hyuck Moon Kwon, and Chul-Woo Ahn, and Geun Taek Lee, and Boyoung Joung, and Bum Kee Hong, and Young Won Yoon, and Dongsoo Kim, and Ki-Hyun Byun, and Tae Soo Kang, and Se-Jung Yoon, and Sung Woo Kwon, and Sung-Ju Lee, and Jong-Kwan Park, and Hyun-Seung Kim
Increased serum advanced glycation end products are associated with impairment in HDL antioxidative capacity in diabetic nephropathy.
March 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Copied contents to your clipboard!