A simple model of radiation action in cells based on a repair saturation mechanism. 1992

A Sánchez-Reyes
Servicio de Radioterapia, Hospital Clínico y Provincial de Barcelona, Spain.

This paper describes a new theoretical model for the response of cells to radiation. This model is based on the existence of a lesion interaction mechanism in the cell, along with processes of recovery and repair that are able to repair the damage produced by radiation in the cells. Such a mechanism makes the cells evolve from a sublethal state to a normal one. Repair and recovery are not instantaneous, but are produced over an average period that we suppose is represented by an exponential function. The probability of cellular recovery and repair is also affected by radiation. These mechanisms become less probable as the dose administered to the cell increases (repair saturation mechanism). This model is suitable for instantaneous doses as well as for arbitrary dose rates. Results obtained from the model for normal tissues and low doses are approximately equal to those obtained by the linear-quadratic model or by the incomplete repair model. The model yields a survival curve with an exponential tail for high doses and for long periods of irradiation.

UI MeSH Term Description Entries
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D004260 DNA Repair The removal of DNA LESIONS and/or restoration of intact DNA strands without BASE PAIR MISMATCHES, intrastrand or interstrand crosslinks, or discontinuities in the DNA sugar-phosphate backbones. DNA Damage Response
D004307 Dose-Response Relationship, Radiation The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response

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