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Studies on the syntheses of 1-substituted benzimidazole derivatives. 2004

Teresa Kowalska, and Piotr Kowalski, and Andrzej J Bojarski, and Beata Duszyńska
Institute of Organic Chemistry and Technology, Cracow University of Technology, 24 Warszawska Str., 31-155 Cracow, Poland.

Several novel 1-heteroarylalkyl substituted benzimidazoles were synthesized in the reaction of various halogenoalkylheterocycles with benzimidazoles. The structures of the products were confirmed by their spectral and analytical data. The potential biological properties of the new compounds were evaluated using the PASS programme.

UI MeSH Term Description Entries
D002626 Chemistry, Pharmaceutical Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use. Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D001562 Benzimidazoles Compounds with a BENZENE fused to IMIDAZOLES.
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

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