BIOMAT Database Logo BIOMAT Database Logo

Prophylaxis of Salmonella abortus ovis-induced abortion of sheep by a Salmonella typhimurium live vaccine. 1992

K Linde, and V Bondarenko, and V Sviridenko
Institute of Medical Microbiology and Epidemiology, Leipzig University, Germany.

A Salmonella typhimurium live vaccine with optimal level of attenuation for sheep, constructed by means of 'metabolic drift' mutations, was tested for its efficacy in preventing Salmonella abortus ovis-induced abortions. In two field trials in Kirgiziya, 78,000 to 100,000 first delivery sheep received a fully tolerated single dose of 10(9) c.f.u. live vaccine 2 months before to 4 months after insemination. Alternatively, they were immunized twice with commercial inactivated S. abortus ovis vaccine, or they served as non-immunized controls. The S. abortus ovis-induced abortion frequency in the controls was greater than or equal to 30%, in sheep immunized with inactivated vaccine greater than or equal to 11%. In flocks immunized with live vaccine, the S. abortus ovis-induced abortion frequency did not exceed 0.1%. Thus, use of 'metabolic drift' mutations for construction of stable vaccine strains optimally attenuated for the particular host species proved to be relevant to practice.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D005260 Female Females
D000034 Abortion, Veterinary Premature expulsion of the FETUS in animals. Veterinary Abortion,Abortions, Veterinary,Veterinary Abortions
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001428 Bacterial Vaccines Suspensions of attenuated or killed bacteria administered for the prevention or treatment of infectious bacterial disease. Bacterial Vaccine,Bacterin,Vaccine, Bacterial,Vaccines, Bacterial
D012481 Salmonella Infections, Animal Infections in animals with bacteria of the genus SALMONELLA. Animal Salmonella Infection,Animal Salmonella Infections,Infection, Animal Salmonella,Infections, Animal Salmonella,Salmonella Infection, Animal
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2
D012756 Sheep Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS. Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D012757 Sheep Diseases Diseases of domestic and mountain sheep of the genus Ovis. Ovine Diseases,Disease, Ovine,Disease, Sheep,Diseases, Ovine,Diseases, Sheep,Ovine Disease,Sheep Disease
D014611 Vaccination Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis. Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations

Related Publications

K Linde, and V Bondarenko, and V Sviridenko
Infection of sheep in Yorkshire with Salmonella abortus ovis.
March 1969, The Veterinary record,
K Linde, and V Bondarenko, and V Sviridenko
[Trial, in a contaminated environment, of an attenuated lyophilized vaccine against S. abortus ovis abortion in sheep].
January 1984, Annales de recherches veterinaires. Annals of veterinary research,
K Linde, and V Bondarenko, and V Sviridenko
[The course of a Salmonella-abortus-ovis infection in a herd of sheep].
October 1977, Schweizer Archiv fur Tierheilkunde,
K Linde, and V Bondarenko, and V Sviridenko
[Ovine salmonellosis caused by Salmonella abortus ovis].
January 1988, Annales de recherches veterinaires. Annals of veterinary research,
K Linde, and V Bondarenko, and V Sviridenko
Abortion storm induced by the live C. abortus vaccine 1B strain in a vaccinated sheep flock, mimicking a natural wild-type infection.
November 2018, Veterinary microbiology,
K Linde, and V Bondarenko, and V Sviridenko
On the prophylaxis of Salmonella sheep abortion.
February 1949, La Clinica veterinaria,
K Linde, and V Bondarenko, and V Sviridenko
[Characteristics of a Salmonella abortus ovis allergen].
January 1981, Veterinarno-meditsinski nauki,
K Linde, and V Bondarenko, and V Sviridenko
Cross-protection against Salmonella Typhimurium infection conferred by a live attenuated Salmonella Enteritidis vaccine.
January 2015, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire,
K Linde, and V Bondarenko, and V Sviridenko
[Experimental infection of sheep with Salmonella abortus ovis: effect of the gestational stage].
January 1984, Annales de recherches veterinaires. Annals of veterinary research,
K Linde, and V Bondarenko, and V Sviridenko
Duration of immunity induced in chickens by an attenuated live Salmonella enteritidis vaccine and an inactivated Salmonella enteritidis/typhimurium vaccine.
January 2011, Berliner und Munchener tierarztliche Wochenschrift,
Copied contents to your clipboard!