Treatment of tumours greater than 2 cm by radiofrequency (RF) or microwave ablation typically use multiple sequential applications, since most currently available ablation devices are limited to use of a single applicator at a time. A major focus of current ablation research is on methodologies that allow increasing the coagulation zone to more rapidly treat large tumours. The ability to use multiple applicators simultaneously would satisfy this need. It would significantly reduce treatment time and may lead to a reduction in local tumour progression, especially in perivascular locations. Several methods have been suggested that potentially allow simultaneous use of multiple applicators, both with radiofrequency (RF) and microwave (MW) ablation. This review compares the different methods of multiple applicator use, investigating advantages and disadvantages of each modality.