Despite development of new diagnostic and therapeutic methods bleeding from peptic ulcer is still associated with high rate of complications and mortality. Apart from endoscopic therapy, pharmacological treatment is of great importance. Affecting platelet aggregation and fibrin formation low pH level of gastric juice impairs processes of coagulation. The fastest and most stable control of acid secretion is achieved by proton pump inhibitors. In the cases of active bleeding from peptic ulcer or signs of recent bleeding such as visible vessel or adhering clot, administration of high doses of proton pump inhibitors by continuous intravenous infusion significantly reduces bleeding recurrence rate. Among patients with Helicobacter pylori (H. pylori) infection, eradication of the bacteria after bleeding episode is mandatory.