Semantic feature knowledge and picture naming in dementia of Alzheimer's type: a new approach. 2005

Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
Institute of Cognitive Neuroscience, Alexandra House, 17 Queen Square, London WC1N 3AR, UK. p.garrard@ucl.ac.uk

This study addresses continuing controversies concerning the nature of semantic impairment in early dementia of the Alzheimer type (DAT), and the relationship between conceptual knowledge and picture naming. A series of analyses of fine-grained feature knowledge data show that: (1) distinctive features of concepts were more vulnerable than shared; (2) the amount of attribute knowledge about a concept was associated reliably, and in a graded fashion, with the ability to name a picture of that item; (3) sensory features were differentially important in naming; and (4) the degree of disruption to different types of attribute knowledge did not vary between items from living and nonliving domains. These findings are discussed in the context of contemporary cognitive and computational models of semantic memory organisation.

UI MeSH Term Description Entries
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010364 Pattern Recognition, Visual Mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs. Recognition, Visual Pattern,Visual Pattern Recognition
D003071 Cognition Intellectual or mental process whereby an organism obtains knowledge. Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia

Related Publications

Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
September 1997, Neuropsychologia,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
February 1997, Journal of clinical and experimental neuropsychology,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
January 2008, Brain and language,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
January 2011, Neuropsychology,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
June 2000, Journal of clinical and experimental neuropsychology,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
August 1996, Brain and language,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
August 2000, The Quarterly journal of experimental psychology. A, Human experimental psychology,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
January 1991, Neuropsychologia,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
November 1990, Brain and language,
Peter Garrard, and Matthew A Lambon Ralph, and Karalyn Patterson, and Katherine H Pratt, and John R Hodges
April 2008, Brain and language,
Copied contents to your clipboard!