Biomaterial Database

Investigation on lymphocyte subpopulations in the intestinal lamina propria in inflammatory bowel diseases. 1992

S Z Yuan, and L P Foster, and N S Wang, and S C Kraft

Gastrointestinal Research Laboratory, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou.

Intestinal lamina proprial lymphocytes were enumerated in 13 patients with Crohn's disease (CD), 7 with ulcerative colitis (UC) and 9 control subjects with grossly normal bowel. The percentages and absolute numbers of B cells and complement receptor-bearing lymphocytes in the patients with UC did not differ significantly from those of the control group; but in CD, the percentages of these cells were significantly decreased despite that the absolute numbers were normal. The percentages and absolute numbers of T cells identified by E rosettes (regular and stable) were normal in both CD and UC. In both diseases, significantly increased percentages but normal absolute numbers of mature T cells were identified by monoclonal antibody staining with the CD3 reagent. There was an increased proportion of suppressor/cytotoxic T cells and a concomitant significant decrease of the helper to suppressor T-cell ratio (using either percentages or absolute numbers of cells) in tissues from patients with CD, but not with UC as compared with the control group. These results suggest that the imbalance of T-cell subpopulations in the intestinal lamina propria may play a role in the pathogenesis of CD.

UI	MeSH Term	Description	Entries
D007413	Intestinal Mucosa	Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.	Intestinal Epithelium,Intestinal Glands,Epithelium, Intestinal,Gland, Intestinal,Glands, Intestinal,Intestinal Gland,Mucosa, Intestinal
D003093	Colitis, Ulcerative	Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.	Colitis Gravis,Idiopathic Proctocolitis,Inflammatory Bowel Disease, Ulcerative Colitis Type,Ulcerative Colitis
D003424	Crohn Disease	A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.	Colitis, Granulomatous,Enteritis, Granulomatous,Enteritis, Regional,Ileitis, Regional,Ileitis, Terminal,Ileocolitis,Crohn's Disease,Crohn's Enteritis,Inflammatory Bowel Disease 1,Regional Enteritis,Crohns Disease,Granulomatous Colitis,Granulomatous Enteritis,Regional Ileitides,Regional Ileitis,Terminal Ileitis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000911	Antibodies, Monoclonal	Antibodies produced by a single clone of cells.	Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D016176	T-Lymphocyte Subsets	A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.	T-Cell Subset,T-Cell Subsets,T-Lymphocyte Subset,Subset, T-Cell,Subset, T-Lymphocyte,Subsets, T-Cell,Subsets, T-Lymphocyte,T Cell Subset,T Cell Subsets,T Lymphocyte Subset,T Lymphocyte Subsets
D016516	CD4-CD8 Ratio	Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.	T4-T8 Ratio,CD4 CD8 Ratio,CD4-CD8 Ratios,T4 T8 Ratio,T4-T8 Ratios