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At perimenopausal stage, women start losing their bone mineral density. The bone loss results from accelerated bone absorption due to lower estrogen level which often caused climacteric disorders. Then it is possible to treat both osteoporosis and climacteric disorders with estrogen replacement therapy. However, it is necessary that we properly explain the hormone-related disorders (breast cancer, endometrial cancer and heart disease) and get the informed consent at beginning of this therapy.
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