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Malignant cells non-randomly and preferentially disseminate to certain distant organs. Of note, breast, prostate and lung cancer and multiple myeloma have a strong predilection for spreading to bone. One of the proposed mechanisms is that these cancer cells express receptors and corresponding cell adhesion molecules (CAMs) for the extracellular matrices (ECMs) and CAMs that are present in the bone microenvironment. Here, the role of integrins and cadherins in bone metastasis will be described.
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