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Alterations in intestinal permeability reflect one component of intestinal epithelial barrier function. The objective of this study was to assess the degree of derangement of intestinal permeability in critically ill patients and to investigate the relationship of this to markers of disease severity and sepsis. Sixteen patients admitted to the intensive care unit for a variety of problems were studied with the severity of illness and degree of sepsis recorded daily. A differential sugar absorption test, using lactulose and mannitol as markers, was performed, and in 10 patients this was repeated after an interval of between 4-11 days. The use of the lactulose/mannitol (L/M) ratio corrects for variables unrelated to permeability such as gastric emptying. The L/M ratio was significantly higher in patients (median 0.98) compared to normal controls (median 0.008). The ratios showed no relation to disease severity or sepsis. These results establish that increased intestinal permeability occurs in the general ICU patient but that it is not uniquely related to sepsis. The extent of this abnormality suggests that further study is required to show the various influences on this process.
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
January 2002,
The European journal of surgery = Acta chirurgica,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
May 2005,
Critical care medicine,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
January 2019,
Nutrition (Burbank, Los Angeles County, Calif.),
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
August 2019,
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
February 2020,
Journal of investigative medicine : the official publication of the American Federation for Clinical Research,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
October 2015,
Medizinische Klinik, Intensivmedizin und Notfallmedizin,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
November 2021,
Acute and critical care,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
August 1998,
American journal of respiratory and critical care medicine,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
March 1979,
Intensive care medicine,
C E Harris, and
R D Griffiths, and
N Freestone, and
D Billington, and
S T Atherton, and
R R Macmillan
January 1995,
JPEN. Journal of parenteral and enteral nutrition,
