BIOMAT Database Logo BIOMAT Database Logo

The mannose receptor mediates the cellular immune response in human coccidioidomycosis. 2005

Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
Department of Medicine, University of Arizona Health Sciences Center, Tucson, Arizona, USA. nampel@email.arizona.edu

Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K. These data suggest that MR mediates IL-2 release by T27K.

UI MeSH Term Description Entries
D007376 Interleukin-2 A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes. IL-2,Lymphocyte Mitogenic Factor,T-Cell Growth Factor,TCGF,IL2,Interleukin II,Interleukine 2,RU 49637,RU-49637,Ro-23-6019,Ro-236019,T-Cell Stimulating Factor,Thymocyte Stimulating Factor,Interleukin 2,Mitogenic Factor, Lymphocyte,RU49637,Ro 23 6019,Ro 236019,Ro236019,T Cell Growth Factor,T Cell Stimulating Factor
D011956 Receptors, Cell Surface Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands. Cell Surface Receptor,Cell Surface Receptors,Hormone Receptors, Cell Surface,Receptors, Endogenous Substances,Cell Surface Hormone Receptors,Endogenous Substances Receptors,Receptor, Cell Surface,Surface Receptor, Cell
D003047 Coccidioidomycosis Infection with a fungus of the genus COCCIDIOIDES, endemic to the SOUTHWESTERN UNITED STATES. It is sometimes called valley fever but should not be confused with RIFT VALLEY FEVER. Infection is caused by inhalation of airborne, fungal particles known as arthroconidia, a form of FUNGAL SPORES. A primary form is an acute, benign, self-limited respiratory infection. A secondary form is a virulent, severe, chronic, progressive granulomatous disease with systemic involvement. It can be detected by use of COCCIDIOIDIN. Coccidioides Infection,Coccidioides posadasii Infection,Coccidioidomycosis Infection,Coccidioides immitis Infection,San Joaquin Valley Fever,Valley Fever,Coccidioides Infections,Coccidioides immitis Infections,Coccidioides posadasii Infections,Coccidioidomycoses,Coccidioidomycosis Infections,Infection, Coccidioides,Infection, Coccidioides immitis,Infection, Coccidioides posadasii,Infection, Coccidioidomycosis,Valley Fevers
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000090323 Mannose Receptor A member of a family of endocytic receptors. Highly expressed on human macrophages, involved in regulating endocytosis, phagocytosis, and immune responses. CD206 Antigen,Cluster of Differentiation 206,MRC1 Protein,Mannose Receptors,Mannose-Fucose Receptor,Mannosyl-Fucosyl Receptor,Receptor, Mannose,206 Cluster, Differentiation,Antigen, CD206,Differentiation 206 Cluster,Mannose Fucose Receptor,Protein, MRC1,Receptor, Mannose-Fucose
D000946 Antigens, Fungal Substances of fungal origin that have antigenic activity. Fungal Antigen,Fungal Antigens,Antigen, Fungal
D037181 Lectins, C-Type A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins. C-Type Lectin Receptor,C-Type Lectins,C-Type Lectin,Lectin, C-Type,Receptors, C-Type Lectin,C Type Lectin,C Type Lectin Receptor,C Type Lectins,C-Type Lectin Receptors,Lectin Receptor, C-Type,Lectin Receptors, C-Type,Lectin, C Type,Lectins, C Type,Receptor, C-Type Lectin,Receptors, C Type Lectin
D037241 Mannose-Binding Lectins A subclass of lectins that are specific for CARBOHYDRATES that contain MANNOSE. Mannose-Specific Lectin,Lectin, Mannose-Specific,Lectins, Mannose-Binding,Mannose Binding Lectins,Mannose Specific Lectin

Related Publications

Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
Cellular immune response in coccidioidomycosis.
February 1975, Cellular immunology,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
Mannose Receptor Mediates the Immune Response to Ganoderma atrum Polysaccharides in Macrophages.
January 2017, Journal of agricultural and food chemistry,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
Role of the mannose receptor in the immune response.
September 2001, Current molecular medicine,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
The immune response in Coccidioidomycosis.
December 2010, Autoimmunity reviews,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
THE LOCAL CELLULAR RESPONSE IN PATIENTS WITH COCCIDIOIDOMYCOSIS.
December 1963, Archives of dermatology,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides.
December 2013, Journal of immunology (Baltimore, Md. : 1950),
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
Measurement of cellular immunity in human coccidioidomycosis.
January 2003, Mycopathologia,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
The mannose receptor mediates dengue virus infection of macrophages.
February 2008, PLoS pathogens,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
[Cellular immune response in human Mycoplasma infection].
January 1982, Trudy Instituta imeni Pastera,
Neil M Ampel, and Daniel K Nelson, and Lijin Li, and Sara O Dionne, and Douglas F Lake, and Keira A Simmons, and Demosthenes Pappagianis
Human mannose receptor (CD206) in immune response: novel insights into vaccination strategies using a humanized mouse model.
September 2007, Expert review of clinical immunology,
Copied contents to your clipboard!