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Prospective ke screening of potential carcinogens being tested in rodent bioassays by the US National Toxicology Program. 1992

G Bakale, and R D McCreary
Case Western Reserve University, Radiology Department, Cleveland, OH 44106-5000.

Values of ke, the rate constant of electron attachment, were measured in cyclohexane for 31 of 44 chemicals now being screened for carcinogenicity in rodent bioassays conducted by the US National Toxicology Program (NTP). These kes provide a physico-chemical measure of electron-solute interaction in a non-polar medium which had been found to be correlated with solute carcinogenicity in our earlier studies of the kes of chemical carcinogens and putative noncarcinogens. The ke test yields 15 negative and 16 positive responses for the 31 chemicals that were screened in this study. These ke results are compared with the predictions of other carcinogen-screening methods that have been applied to the same chemicals and also reported in this Discussion Forum.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009313 National Health Programs Components of a national health care system which administer specific services, e.g., national health insurance. National Health Insurance, Non-U.S.,Health Services, National,National Health Insurance,National Health Insurance, Non U.S.,National Health Services,Services, National Health,Health Insurance, National,Health Program, National,Health Programs, National,Health Service, National,Insurance, National Health,National Health Program,National Health Service,Program, National Health,Programs, National Health,Service, National Health
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004563 Electrochemistry The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes. Electrochemistries
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012377 Rodentia A mammalian order which consists of 29 families and many genera. Beavers,Capybaras,Castor Beaver,Dipodidae,Hydrochaeris,Jerboas,Rodents,Beaver,Capybara,Hydrochaeri,Jerboa,Rodent,Rodentias
D014481 United States A country in NORTH AMERICA between CANADA and MEXICO.

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