BIOMAT Database Logo BIOMAT Database Logo

Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. 2005

Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
Dipartimento di Scienze e Tecnologie Biomediche, Università di L'Aquila, L'Aquila, Italy.

A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D002442 Ceftazidime Semisynthetic, broad-spectrum antibacterial derived from CEPHALORIDINE and used especially for Pseudomonas and other gram-negative infections in debilitated patients. Ceftazidime Anhydrous,Ceftazidime Pentahydrate,Fortaz,Fortum,GR-20263,LY-139381,Pyridinium, 1-((7-(((2-amino-4-thiazolyl)((1-carboxy-1-methylethoxy)imino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-, inner salt, pentahydrate, (6R-(6alpha,7beta(Z)))-,Tazidime,GR 20263,GR20263,LY 139381,LY139381
D004756 Enterobacteriaceae Infections Infections with bacteria of the family ENTEROBACTERIACEAE. Enterobacterial Infections,Cronobacter Infections,Infections, Enterobacteriaceae,Infections, Enterobacterial,Cronobacter Infection,Enterobacteriaceae Infection,Enterobacterial Infection,Infection, Cronobacter,Infection, Enterobacteriaceae,Infection, Enterobacterial,Infections, Cronobacter
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001618 beta-Lactamases Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins. beta-Lactamase,beta Lactamase,beta Lactamases
D017422 Sequence Analysis, DNA A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis. DNA Sequence Analysis,Sequence Determination, DNA,Analysis, DNA Sequence,DNA Sequence Determination,DNA Sequence Determinations,DNA Sequencing,Determination, DNA Sequence,Determinations, DNA Sequence,Sequence Determinations, DNA,Analyses, DNA Sequence,DNA Sequence Analyses,Sequence Analyses, DNA,Sequencing, DNA
D018550 Cephalosporin Resistance Non-susceptibility of an organism to the action of the cephalosporins. Cephalosporin Resistances,Resistance, Cephalosporin,Resistances, Cephalosporin
D024881 Drug Resistance, Bacterial The ability of bacteria to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS). Antibiotic Resistance, Bacterial,Antibacterial Drug Resistance

Related Publications

Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
Biochemical analysis of TEM-134, a new TEM-type extended-spectrum beta-lactamase variant produced in a Citrobacter koseri clinical isolate from an Italian hospital.
October 2007, The Journal of antimicrobial chemotherapy,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
CTX-M-35 extended-spectrum beta-lactamase conferring ceftazidime resistance in Citrobacter koseri.
April 2010, International journal of antimicrobial agents,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar Infantis.
September 2006, Antimicrobial agents and chemotherapy,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
TEM-71, a novel plasmid-encoded, extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae.
June 2002, Antimicrobial agents and chemotherapy,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
SHV-type extended-spectrum beta-lactamase in a Shigella flexneri clinical isolate.
May 2001, The Journal of antimicrobial chemotherapy,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
TEM-21 extended-spectrum beta-lactamase in a clinical isolate of Alcaligenes faecalis from a nursing home.
February 2006, The Journal of antimicrobial chemotherapy,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
Characterization of a novel extended-spectrum TEM-type beta-lactamase, TEM-164, in a clinical strain of Klebsiella pneumoniae in Tunisia.
September 2009, Microbial drug resistance (Larchmont, N.Y.),
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
Novel extended-spectrum TEM-type beta-lactamase from an Escherichia coli isolate resistant to ceftazidime and susceptible to cephalothin.
March 1997, Antimicrobial agents and chemotherapy,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
Two variants of transferrable extended-spectrum TEM-beta-lactamase successively isolated from a clinical Escherichia coli isolate.
June 1992, FEMS microbiology letters,
Mariagrazia Perilli, and Claudia Mugnaioli, and Francesco Luzzaro, and Marianna Fiore, and Stefania Stefani, and Gian Maria Rossolini, and Gianfranco Amicosante
A novel complex mutant beta-lactamase, TEM-68, identified in a Klebsiella pneumoniae isolate from an outbreak of extended-spectrum beta-lactamase-producing Klebsiellae.
June 2000, Antimicrobial agents and chemotherapy,
Copied contents to your clipboard!