The incidence of gastric cancer in the Republic is characterized by some features related to local natural conditions, ethnic and socio-economic factors. These features comprise variations in the gastric cancer incidence in separate climatic-geographical zones. A higher morbidity rate was noted in Chuisk valley in the north of the Republic. The lowest morbidity rate was recorded in Osha Province. The index of the gastric cancer morbidity among Russian population is higher than among Kirghiz and Uzbek nationalities. During recent years there is a tendency to the reduced morbidity and mortality due to cancer of the stomach in the Republic.