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This report defines the bone marrow-derived elements found in the central nervous system of adult rat radiation chimeras. Four cell types were identified which bore the major histocompatibility (MHC) class I molecules of the donor rat strain thereby indicating a marrow origin. They were: meningeal macrophages, perivascular "microglial" cells, lymphocytes and rare cells with parenchymal microglial morphology. These cells were examined by immunohistochemical methods at the light microscopic and ultrastructural levels. Extended descriptions of the perivascular marrow-derived elements and the parenchymal microglial cells are presented. These latter two cell types, which exist in humans, have a significant role in neuroimmune processes and most probably function as the antigen-presenting cells in the central nervous system of mammals.
W F Hickey, and
K Vass, and
H Lassmann
June 1990,
Neurologia medico-chirurgica,
W F Hickey, and
K Vass, and
H Lassmann
January 1997,
Acta neurochirurgica,
W F Hickey, and
K Vass, and
H Lassmann
June 2004,
The Journal of comparative neurology,
W F Hickey, and
K Vass, and
H Lassmann
December 1988,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
W F Hickey, and
K Vass, and
H Lassmann
September 1977,
Proceedings of the National Academy of Sciences of the United States of America,
W F Hickey, and
K Vass, and
H Lassmann
December 1987,
Journal of neuroimmunology,
W F Hickey, and
K Vass, and
H Lassmann
January 2001,
Journal of immunology (Baltimore, Md. : 1950),
W F Hickey, and
K Vass, and
H Lassmann
October 2007,
Bone marrow transplantation,
W F Hickey, and
K Vass, and
H Lassmann
May 2004,
The Journal of comparative neurology,
W F Hickey, and
K Vass, and
H Lassmann
December 2013,
The Journal of comparative neurology,
