Biomaterial Database

Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats. 2005

Małgorzata Filip

Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. filip@if-pan.krakow.pl

Previous studies have indicated a role of serotonin (5-HT)2 receptors in modulation of the behavioral effects of cocaine. In the present study, the efficacy of SR 46349B (a 5-HT(2A) receptor antagonist) or SDZ SER-082 (a 5-HT(2C) receptor antagonist) in altering cocaine seeking behavior was examined in rats. Rats were trained to press a lever for cocaine (0.5 mg/kg/infusion, iv) paired with the cue (light + tone). After stabilization of self-administration response, the animals underwent daily extinction sessions during which responding had no consequences. The cocaine seeking behavior was reinstated by cocaine priming (10 mg/kg, ip) or by presentation of the cue. Neither SR 46349B (0.25-1 mg/kg) nor SDZ SER-082 (0.25-1 mg/kg) altered the maintenance of cocaine self-administration. SR 46349B (0.5-1 mg/kg) decreased responding to the cocaine priming dose and reduced cue-induced reinstatement, while SDZ SER-082 failed to alter both cue- and cocaine priming-induced reinstatement. These findings indicate that 5-HT(2A) and 5-HT(2C) receptors are not significant to cocaine rewarding effects. However, they show the importance of the 5-HT(2A) receptors (but not 5-HT(2C) receptors) in cocaine-priming- and cue-provoked reinstatement. Since drugs that reduce cocaine seeking also alleviate cocaine craving, 5-HT(2A) receptor antagonists may be considered to be of possible clinical application for the treatment of cocaine dependence.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010636	Phenols	Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D003042	Cocaine	An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.	Cocaine HCl,Cocaine Hydrochloride,HCl, Cocaine,Hydrochloride, Cocaine
D005464	Fluorobenzenes	Derivatives of BENZENE that contain FLUORINE.	Fluorobenzene
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001522	Behavior, Animal	The observable response an animal makes to any situation.	Autotomy Animal,Animal Behavior,Animal Behaviors
D012646	Self Administration	Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal.	Administration, Self,Administrations, Self,Self Administrations
D012702	Serotonin Antagonists	Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or SEROTONIN RECEPTOR AGONISTS.	5-HT Antagonist,5-HT Antagonists,5-Hydroxytryptamine Antagonist,5-Hydroxytryptamine Antagonists,Antiserotonergic Agent,Antiserotonergic Agents,Serotonin Antagonist,Serotonin Blockader,Serotonin Blockaders,Serotonin Receptor Antagonist,Serotonin Receptor Blocker,Antagonists, 5-HT,Antagonists, 5-Hydroxytryptamine,Antagonists, Serotonin,Serotonin Receptor Antagonists,Serotonin Receptor Blockers,5 HT Antagonist,5 HT Antagonists,5 Hydroxytryptamine Antagonist,5 Hydroxytryptamine Antagonists,Agent, Antiserotonergic,Agents, Antiserotonergic,Antagonist, 5-HT,Antagonist, 5-Hydroxytryptamine,Antagonist, Serotonin,Antagonist, Serotonin Receptor,Antagonists, 5 HT,Antagonists, 5 Hydroxytryptamine,Antagonists, Serotonin Receptor,Blockader, Serotonin,Blockaders, Serotonin,Blocker, Serotonin Receptor,Blockers, Serotonin Receptor,Receptor Antagonist, Serotonin,Receptor Antagonists, Serotonin,Receptor Blocker, Serotonin,Receptor Blockers, Serotonin
D017208	Rats, Wistar	A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.	Wistar Rat,Rat, Wistar,Wistar Rats
D044348	Receptors, Serotonin, 5-HT2	A subclass of G-protein coupled SEROTONIN receptors that couple preferentially to the GQ-G11 G-PROTEINS resulting in increased intracellular levels of INOSITOL PHOSPHATES and free CALCIUM.	Serotonin 5-HT2 Receptors,Serotonin Receptors, 5-HT2,5-HT-2 Receptors,Receptors, 5-HT-2,Receptors, Serotonin S2,Receptors, Serotonin-2,Serotonin S2 Receptors,Serotonin-2 Receptors,5 HT 2 Receptors,5-HT2 Receptors, Serotonin,5-HT2 Serotonin Receptors,Receptors, 5 HT 2,Receptors, 5-HT2 Serotonin,Receptors, Serotonin 2,Receptors, Serotonin 5-HT2,S2 Receptors, Serotonin,Serotonin 2 Receptors,Serotonin 5 HT2 Receptors,Serotonin Receptors, 5 HT2