BIOMAT Database Logo BIOMAT Database Logo

Human immunodeficiency virus type 1 enhances intracellular growth of Mycobacterium avium in human macrophages. 1992

G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
National Bacteriological Laboratory, Karolinska Institute, Stockholm, Sweden.

Disseminated Mycobacterium avium infections are common in patients with AIDS and result in a reduced life expectancy. Human monocytes/macrophages are important target cells for both human immunodeficiency virus (HIV) and M. avium. We have studied the interaction in vitro of M. avium and HIV type 1 (HIV-1) in human macrophages. Human monocytes isolated from the peripheral blood of healthy individuals were infected with HIV-1, M. avium, or both. The intracellular growth of M. avium and the replication of HIV-1 were monitored for up to 5 weeks. Intracellular mycobacterial growth was seen in all M. avium infected cell cultures and was paralleled by increased production of interleukin 1 alpha and beta. Preinfection of the macrophages with HIV-1 reduced the interleukin 1 production and accelerated the intracellular growth of M. avium. These findings may explain in part the impaired control of mycobacterial infections seen with patients with AIDS.

UI MeSH Term Description Entries
D007375 Interleukin-1 A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation. IL-1,Lymphocyte-Activating Factor,Epidermal Cell Derived Thymocyte-Activating Factor,Interleukin I,Macrophage Cell Factor,T Helper Factor,Epidermal Cell Derived Thymocyte Activating Factor,Interleukin 1,Lymphocyte Activating Factor
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D009162 Mycobacterium avium A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014779 Virus Replication The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle. Viral Replication,Replication, Viral,Replication, Virus,Replications, Viral,Replications, Virus,Viral Replications,Virus Replications
D015497 HIV-1 The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte. Human immunodeficiency virus 1,HIV-I,Human Immunodeficiency Virus Type 1,Immunodeficiency Virus Type 1, Human

Related Publications

G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Interaction between Mycobacterium avium and human immunodeficiency virus type 1 (HIV-1) in bronchoalveolar macrophages of normal and HIV-1-infected subjects.
October 1994, American journal of respiratory cell and molecular biology,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Comparison of the intracellular activities of clarithromycin and erythromycin against Mycobacterium avium complex strains in J774 cells and in alveolar macrophages from human immunodeficiency virus type 1-infected individuals.
May 1992, Antimicrobial agents and chemotherapy,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Multiple determinants for growth of human immunodeficiency virus type 1 in monocyte-macrophages.
January 1995, Virology,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Intracellular growth of Mycobacterium avium subspecies and global transcriptional responses in human macrophages after infection.
January 2014, BMC genomics,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Intracellular activity of azithromycin against Mycobacterium avium complex in human macrophages.
July 1997, Arzneimittel-Forschung,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Involvement of matrix metalloproteinases in human immunodeficiency virus type 1-induced replication by clinical Mycobacterium avium isolates.
October 1999, The Journal of infectious diseases,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Human immunodeficiency virus type 1 tropism for human macrophages.
January 1992, Pathobiology : journal of immunopathology, molecular and cellular biology,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Mycobacterium tuberculosis enhances human immunodeficiency virus-1 replication in the lung.
March 1997, American journal of respiratory and critical care medicine,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Tumor necrosis factor-alpha/cachectin enhances human immunodeficiency virus type 1 replication in primary macrophages.
January 1991, The Journal of infectious diseases,
G Källenius, and T Koivula, and K J Rydgård, and S E Hoffner, and A Valentin, and B Asjö, and C Ljungh, and U Sharma, and S B Svenson
Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages.
September 1994, Journal of immunology (Baltimore, Md. : 1950),
Copied contents to your clipboard!