Altered renal elimination of organic anions in rats with chronic renal failure. 2005

Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
Farmacología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, CONICET, Argentina. adtorres@fbioyf.unr.edu.ar

The progress of chronic renal failure (CRF) is characterized by the development of glomerular and tubular lesions. However, little is known about the expression of organic anions renal transporters. The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). Two groups of animals were used: Sham and CRF. Six months after surgery, systolic blood pressure and plasma creatinine concentrations were significantly higher in CRF groups. CRF rats showed a diminution in: the filtered, secreted and excreted load of PAH; the systemic clearance of PAH; the renal OAT1 expression; and the renal Na-K-ATPase activity. No remarkable modifications were observed in the OAT3 expression from CRF kidneys. The diminution in the systemic depuration and renal excretion of PAH may be explained by the decrease in its filtered and secreted load. The lower OAT1 expression in remnant renal mass of CRF rats or/and the lower activity of Na-K-ATPase might justify, at least in part, the diminished secreted load of this organic anion.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D008297 Male Males
D010130 p-Aminohippuric Acid The glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. 4-Aminohippuric Acid,para-Aminohippuric Acid,Aminohippurate Sodium,Aminohippuric Acid,Nephrotest,Sodium Para-Aminohippurate,p-Aminohippurate,4 Aminohippuric Acid,Para-Aminohippurate, Sodium,Sodium Para Aminohippurate,Sodium, Aminohippurate,p Aminohippurate,p Aminohippuric Acid,para Aminohippuric Acid
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D000254 Sodium-Potassium-Exchanging ATPase An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. ATPase, Sodium, Potassium,Adenosinetriphosphatase, Sodium, Potassium,Na(+)-K(+)-Exchanging ATPase,Na(+)-K(+)-Transporting ATPase,Potassium Pump,Sodium Pump,Sodium, Potassium ATPase,Sodium, Potassium Adenosinetriphosphatase,Sodium-Potassium Pump,Adenosine Triphosphatase, Sodium, Potassium,Na(+) K(+)-Transporting ATPase,Sodium, Potassium Adenosine Triphosphatase,ATPase Sodium, Potassium,ATPase, Sodium-Potassium-Exchanging,Adenosinetriphosphatase Sodium, Potassium,Pump, Potassium,Pump, Sodium,Pump, Sodium-Potassium,Sodium Potassium Exchanging ATPase,Sodium Potassium Pump
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000838 Anions Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis. Anion
D017208 Rats, Wistar A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain. Wistar Rat,Rat, Wistar,Wistar Rats

Related Publications

Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
April 2004, Biochimica et biophysica acta,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
November 2008, World journal of gastroenterology,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
May 1994, Journal of the American Society of Nephrology : JASN,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
May 1994, Journal of the American Society of Nephrology : JASN,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
March 2013, Journal of pharmaceutical sciences,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
December 1986, Infusionstherapie und klinische Ernahrung,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
January 2008, Postepy biochemii,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
May 1994, Polskie Archiwum Medycyny Wewnetrznej,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
September 1986, Archives internationales de pharmacodynamie et de therapie,
Adriana Mónica Torres, and Myriam Mac Laughlin, and Angélica Muller, and Anabel Brandoni, and Naohiko Anzai, and Hitoshi Endou
July 1974, Kidney international,
Copied contents to your clipboard!