Biomaterial Database

Extrahepatic manifestations of cholestatic liver diseases: pathogenesis and therapy. 2005

Thomas Pusl, and Ulrich Beuers

Department of Medicine II, Klinikum of the University of Munich-Grosshadern, Munich, Germany.

Pruritus, fatigue, and metabolic bone disease are frequent complications of cholestatic liver diseases, which can be quite distressing for the patient and can considerably reduce the quality of life. The molecular pathogenesis of these extrahepatic manifestations of cholestasis is poorly understood, and hypotheses to explain these symptoms are being discussed. This article provides treatment recommendations for the complications of cholestasis based on putative pathomechanisms and summarizes recent experimental and clinical data involving management options.

UI	MeSH Term	Description	Entries
D011537	Pruritus	An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.	Itching,Pruritis
D001851	Bone Diseases, Metabolic	Diseases that affect the METABOLIC PROCESSES of BONE TISSUE.	Low Bone Density,Low Bone Mineral Density,Osteopenia,Metabolic Bone Diseases,Bone Density, Low,Bone Disease, Metabolic,Low Bone Densities,Metabolic Bone Disease,Osteopenias
D002779	Cholestasis	Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).	Bile Duct Obstruction,Biliary Stasis,Bile Duct Obstructions,Biliary Stases,Cholestases,Duct Obstruction, Bile,Duct Obstructions, Bile,Obstruction, Bile Duct,Obstructions, Bile Duct,Stases, Biliary,Stasis, Biliary
D005221	Fatigue	The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.	Lassitude
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015209	Cholangitis, Sclerosing	Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.	Cholangiitis, Sclerosing,Cholangitis, Primary Sclerosing,Primary Sclerosing Cholangitis,Sclerosing Cholangitis,Cholangiitides, Sclerosing,Cholangitides, Primary Sclerosing,Cholangitides, Sclerosing,Primary Sclerosing Cholangitides,Sclerosing Cholangiitides,Sclerosing Cholangiitis,Sclerosing Cholangitides,Sclerosing Cholangitides, Primary,Sclerosing Cholangitis, Primary