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Electrical stimulations were applied daily for 40 days to the dorsal tegmentum in 9 rats through chronically implanted bipolar electrodes. The intensity of current (2 s trains of 50 Hz, 1 ms monophasic square waves) necessary to trigger a full tonic seizure was determined and applied for all further stimulations. Initial stimulations induced a tonic seizure with a low voltage fast electrocorticographic activity. After repeated stimulations, high amplitude spike and wave discharges developed over the cortex, their duration exceeding 50 s at the 40th stimulation. Simultaneously, the tonic seizures evolved into tonic-clonic fits with bilateral myoclonias following the tonic phase. These EEG and behavioral modifications persisted for 30 days after the last stimulus. These results demonstrate that kindling may be obtained from brainstem structures.
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
April 1992,
Epilepsy research,
B Maton, and
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M Vergnes, and
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C Marescaux
January 1985,
Experimental neurology,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
January 1982,
Experimental neurology,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
September 1982,
Experimental neurology,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
January 1991,
Progress in brain research,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
July 1974,
Brain research,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
July 1993,
Rinsho shinkeigaku = Clinical neurology,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
December 1997,
Physiology & behavior,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
April 2015,
Basic and clinical neuroscience,
B Maton, and
E Hirsch, and
M Vergnes, and
A Depaulis, and
C Marescaux
March 1975,
Behavioral biology,
