Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related acute myeloid leukemia. 2005

Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
Cytogenetics Laboratory, Department of Pathology, Singapore General Hospital, Block 6, Level 5, Room A4, Outram Road, 169608 Singapore. geokyee@hotmail.com

We describe a patient with acute promyelocytic leukemia (APL) and the karyotype 46,XX,i(17)(q10) with PML-RARA fusion gene detected by fluorescence in situ hybridization (FISH) and nested reverse transcriptase-polymerase chain reaction (RT-PCR). FISH using dual-color translocation probes for PML (promyelocytic leukemia) and RARA (retinoic acid receptor-alpha) showed fusion signal for PML-RARA on both arms of i(17q). The patient attained complete remission (CR) with all-trans retinoic acid treatment and became PML-RARA negative. One year later, while PML-RARA negative on FISH and RT-PCR, the patient presented with thrombocytopenia. Bone marrow examination suggested an acute monoblastic leukemia (AML-M5a) including the karyotype 46,XX,t(8;16) (p11.2;p13.3),inv(11)(p15q22 approximately q23)[11]/47,idem,+i(8)(q10)[9]. She is currently in CR. The occurrence of therapy related acute leukemia after successful therapy for APL is an emerging problem.

UI MeSH Term Description Entries
D007621 Karyotyping Mapping of the KARYOTYPE of a cell. Karyotype Analysis Methods,Analysis Method, Karyotype,Analysis Methods, Karyotype,Karyotype Analysis Method,Karyotypings,Method, Karyotype Analysis,Methods, Karyotype Analysis
D007948 Leukemia, Monocytic, Acute An acute myeloid leukemia in which 80% or more of the leukemic cells are of monocytic lineage including monoblasts, promonocytes, and MONOCYTES. Leukemia, Monoblastic, Acute,Leukemia, Myeloid, Acute, M5,Leukemia, Myeloid, Schilling-Type,Monoblastic Leukemia, Acute,Monocytic Leukemia, Acute,Myeloid Leukemia, Acute, M5,Myeloid Leukemia, Schilling-Type,Leukemia, Acute Monocytic,Leukemia, Myeloid, Schilling Type,Acute Monoblastic Leukemia,Acute Monoblastic Leukemias,Acute Monocytic Leukemia,Acute Monocytic Leukemias,Leukemia, Schilling-Type Myeloid,Leukemias, Acute Monoblastic,Leukemias, Acute Monocytic,Monoblastic Leukemias, Acute,Monocytic Leukemias, Acute,Myeloid Leukemia, Schilling Type,Schilling-Type Myeloid Leukemia
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009363 Neoplasm Proteins Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm. Proteins, Neoplasm
D009687 Nuclear Proteins Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. Nucleolar Protein,Nucleolar Proteins,Nuclear Protein,Protein, Nuclear,Protein, Nucleolar,Proteins, Nuclear,Proteins, Nucleolar
D002886 Chromosomes, Human, Pair 17 A specific pair of GROUP E CHROMOSOMES of the human chromosome classification. Chromosome 17
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071156 Promyelocytic Leukemia Protein A tripartite motif protein that contains three ZINC FINGERS, including a RING FINGER DOMAIN, at its N-terminal. Several nuclear and one cytoplasmic isoforms result from alternative splicing of the PML gene; most nuclear isoforms localize to subnuclear structures (PML nuclear bodies) that are disrupted in ACUTE PROMYELOCYTIC LEUKEMIA cells. RNF71 Protein,TRIM19 Protein
D000072482 Retinoic Acid Receptor alpha A nuclear receptor protein which belongs to a family of transcription regulators of ligand-responsive regulatory proteins which include steroid hormone receptors. In addition to a C-terminal ligand-binding domain, these nuclear receptors contain a highly-conserved N-terminal zinc-finger domain that mediates binding ligand-responsive elements. RAR alpha 1,RAR alpha 2,Retinoic Acid Receptor alpha 1,Retinoic Acid Receptor alpha 2,alpha 1, RAR,alpha 2, RAR

Related Publications

Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
January 2019, Annals of hematology,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
March 1995, Blood,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
October 2002, Cancer genetics and cytogenetics,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
April 2009, British journal of haematology,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
January 2019, Academic pathology,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
October 2009, Clinical cancer research : an official journal of the American Association for Cancer Research,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
November 1992, Leukemia & lymphoma,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
May 2010, Genes, chromosomes & cancer,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
September 2019, Leukemia & lymphoma,
Geok Yee Lee, and Sivaswaren Christina, and Sim Leng Tien, and Anisah Bte Abdul Ghafar, and William Hwang, and Lay Cheng Lim, and Tse Hui Lim
October 2025, International journal of laboratory hematology,
Copied contents to your clipboard!