Biomaterial Database

The role of serotonergic mechanisms on amphetamine-induced stereotyped behaviour. 1978

E B Arushanian, and B A Tolpyshev

The effects of 5-hydroxytryptophan (5-HTP) and p-chlorophenylalanine (PCPA) on amphetamine-induced stereotyped behaviour (ASB) and on the behavioural and EEG effects of caudate nucleus stimulation have been studied in the cat. After a pretreatment with 5-HTP (10--30 mg/kg) the threshold dose of amphetamine to induce ASB remained the same, but its pattern assumed a more organized character with reduced amplitude of stereotyped movements. On the contrary, after PCPA (200 mg/kg) a disorganized pattern of ASB was observed. 5-HTP increased and PCPA decreased the threshold of the arrest reaction induced by low frequency stimulation of ventro-lateral parts of the head of caudate nucleus. 5-HTP and PCPA also influenced in the opposite direction caudate-induced spindle waves in the neocortex. The effects of amphetamine on behavioural and EEG pattern of arrest reaction due to stimulation of the caudate nucleus were antagonized by 5-HTP and potentiated by PCPA. It is supposed that serotonergic mechanisms present in the ventro-lateral regions of the caudate nucleus can modulate stereotyped behaviour triggered by amphetamine.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010134	Fenclonine	A selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). Fenclonine acts pharmacologically to deplete endogenous levels of serotonin.	p-Chlorophenylalanine,para-Chlorophenylalanine,CP-10,188,DL-3-(4-Chlorophenyl)alanine,Fenclonin,Fenclonine (L)-Isomer,Fenclonine Hydrobromide,Fenclonine Hydrochloride,Fenclonine, (D)-Isomer,Hydrobromide, Fenclonine,Hydrochloride, Fenclonine,para Chlorophenylalanine
D002415	Cats	The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)	Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002421	Caudate Nucleus	Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.	Caudatus,Nucleus Caudatus,Caudatus, Nucleus,Nucleus, Caudate
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006916	5-Hydroxytryptophan	The immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.	5-HTP,Hydroxytryptophan,Oxitriptan,Oxytryptophan,Tryptophan, 5-Hydroxy-,5 Hydroxytryptophan,5-Hydroxy- Tryptophan,Tryptophan, 5 Hydroxy
D000661	Amphetamine	A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.	Desoxynorephedrin,Levoamphetamine,Phenopromin,l-Amphetamine,Amfetamine,Amphetamine Sulfate,Amphetamine Sulfate (2:1),Centramina,Fenamine,Mydrial,Phenamine,Thyramine,levo-Amphetamine,Sulfate, Amphetamine,l Amphetamine,levo Amphetamine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001519	Behavior	The observable response of a man or animal to a situation.	Acceptance Process,Acceptance Processes,Behaviors,Process, Acceptance,Processes, Acceptance