BIOMAT Database Logo BIOMAT Database Logo

Outcomes of pregnancy complicated by thyroid disease. 2005

Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Department of Obstetrics & Gynaecology, Glasgow Royal Infirmary, Glasgow, UK. lyndalharborne@yahoo.co.uk

OBJECTIVE To perform a case note review of pregnancies complicated by thyroid dysfunction to determine management and therapeutic intervention in relation to pregnancy outcome. METHODS A retrospective case note analysis of 81 ongoing pregnancies in 70 pregnant women with a history of thyroid dysfunction over a period of 5 years at the Glasgow Royal Maternity Hospital (GRMH), Glasgow, Scotland, United Kingdom. The results of thyroid function tests and whether a change in treatment was instituted were recorded. Thyroid function was assessed by standard laboratory reference ranges for free thyroxine (FT4) and thyroid stimulating hormone (TSH) in all trimesters. Other parameters were also noted. RESULTS Medication levels needed to be increased in the hypothyroid group (45%), and decreased (38%) in the hyperthyroid group. CONCLUSIONS Pregnancy outcome was good in majority of cases given appropriate replacement therapy for stated reference values.

UI MeSH Term Description Entries
D006980 Hyperthyroidism Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE. Hyperthyroid,Primary Hyperthyroidism,Hyperthyroidism, Primary,Hyperthyroids
D007037 Hypothyroidism A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction. Central Hypothyroidism,Primary Hypothyroidism,Secondary Hypothyroidism,TSH Deficiency,Thyroid-Stimulating Hormone Deficiency,Central Hypothyroidisms,Deficiency, TSH,Deficiency, Thyroid-Stimulating Hormone,Hormone Deficiency, Thyroid-Stimulating,Hypothyroidism, Central,Hypothyroidism, Primary,Hypothyroidism, Secondary,Hypothyroidisms,Primary Hypothyroidisms,Secondary Hypothyroidisms,TSH Deficiencies,Thyroid Stimulating Hormone Deficiency,Thyroid-Stimulating Hormone Deficiencies
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011248 Pregnancy Complications Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases. Adverse Birth Outcomes,Complications, Pregnancy,Adverse Birth Outcome,Birth Outcome, Adverse,Complication, Pregnancy,Outcome, Adverse Birth,Pregnancy Complication
D011256 Pregnancy Outcome Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO. Outcome, Pregnancy,Outcomes, Pregnancy,Pregnancy Outcomes
D011441 Propylthiouracil A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) 6-Propyl-2-Thiouracil,6 Propyl 2 Thiouracil
D002231 Carbimazole An imidazole antithyroid agent. Carbimazole is metabolized to METHIMAZOLE, which is responsible for the antithyroid activity. Carbimazole Henning,Neo Tomizol,Neo-Mercazole,Neo-Thyreostat,Neomercazole
D005260 Female Females
D005865 Gestational Age The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination. Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Pregnancy complicated by thyroid disease.
January 1990, Journal of nurse-midwifery,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
[Diagnosis and treatment of autoimmune thyroid disease (ATD) complicated by pregnancy].
August 1999, Nihon rinsho. Japanese journal of clinical medicine,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Molar Pregnancy Complicated by Impending Thyroid Storm.
November 2021, Cureus,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Serum long acting thyroid stimulator protector in pregnancy complicated by Graves' disease.
March 1983, British medical journal (Clinical research ed.),
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Pregnancy complicated by Hodgkin's disease.
August 2006, The Medical journal of Malaysia,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Pregnancy Complicated by Heart Disease.
November 1945, Journal of the National Medical Association,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Pregnancy complicated by Gorham disease.
May 1993, Obstetrics and gynecology,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Hodgkin's disease complicated by pregnancy.
February 1951, Southern medical journal,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Pregnancy complicated by heart disease.
January 1954, Transactions of the New England Obstetrical and Gynecological Society,
Lyndal R Harborne, and Claire E Alexander, and Andrew J Thomson, and Denis St J O'Reilly, and Ian A Greer
Hodgkin's disease complicated by pregnancy.
June 1948, Journal of the American Medical Association,
Copied contents to your clipboard!