Biomaterial Database

Episcleral pseudorheumatoid nodule with a choroidal mass simulating malignant melanoma. 1992

V Lakhanpal, and M R Dogra, and J B Aquilla

Department of Ophthalmology, University of Maryland School of Medicine, Baltimore 21201.

A 47-year-old man had an injected episcleral mass, anterior uveitis, and a grayish white elevated choroidal mass with exudative retinal detachment. Excisional biopsy of the episcleral mass showed pseudorheumatoid nodule. All investigations for rheumatic diseases were negative. Treatment with topical corticosteroids resulted in disappearance of the choroidal mass and resolution of the uveitis. An 11-year follow-up showed no evidence of any rheumatic disease. To the best of our knowledge, this is the first histopathologically confirmed case report where an episcleral pseudorheumatoid nodule presented with a choroidal mass that simulated choroidal malignant melanoma.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008545	Melanoma	A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D012163	Retinal Detachment	Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).	Retinal Pigment Epithelial Detachment,Detachment, Retinal,Detachments, Retinal,Retinal Detachments
D002830	Choroid Neoplasms	Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).	Choroidal Neoplasms,Choroid Neoplasm,Choroidal Neoplasm,Neoplasm, Choroid,Neoplasm, Choroidal,Neoplasms, Choroid,Neoplasms, Choroidal
D003937	Diagnosis, Differential	Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures.	Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D006099	Granuloma	A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.	Granulomas
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014606	Uveitis, Anterior	Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.	Anterior Uveitides,Anterior Uveitis,Uveitides, Anterior
D015422	Scleral Diseases	General disorders of the sclera or white of the eye. They may include anatomic, embryologic, degenerative, or pigmentation defects.	Sclera Diseases,Disease, Sclera,Disease, Scleral,Diseases, Sclera,Diseases, Scleral,Sclera Disease,Scleral Disease