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The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro. 1992
J A Coates, and
N Cammack, and
H J Jenkinson, and
I M Mutton, and
B A Pearson, and
R Storer, and
J M Cameron, and
C R Penn
Department of Virology, Glaxo Group Research Ltd., Greenford, Middlesex, United Kingdom.
Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.
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