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Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives. 2005
Prasad P Dixit, and
Prathap S Nair, and
Vijaykumar J Patil, and
Sanjay Jain, and
Sudershan K Arora, and
Neelima Sinha
Medicinal Chemistry Division, New Chemical Entity Research, Lupin Research Park, 46/47A, Village Nande, Taluka Mulshi, Pune 411 042, Maharashtra, India.
A series of novel (un)substituted benzotriazolyl oxazolidinone derivatives has been synthesized and tested for in vitro antibacterial activities by MIC determination against a panel of susceptible and resistant Gram-positive and Gram-negative microorganisms, some of which are resistant to methicillin and vancomycin. Compounds 20, 21, 24, 29 and 30 from this series were found to be equipotent or more potent than linezolid in vitro.
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