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Protein microarray for profiling antibody responses to Yersinia pestis live vaccine. 2005
Bei Li, and
Lingxiao Jiang, and
Qifeng Song, and
Junxin Yang, and
Zeliang Chen, and
Zhaobiao Guo, and
Dongsheng Zhou, and
Zongmin Du, and
Yajun Song, and
Jin Wang, and
Hongxia Wang, and
Shouyi Yu, and
Jian Wang, and
Ruifu Yang
Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
A protein microarray representing 149 Yersinia pestis proteins was developed to profile antibody responses in EV76-immunized rabbits. Antibodies to 50 proteins were detected. There are 11 proteins besides F1 and V antigens to which the predominant antibody response occurred, and these proteins show promise for further evaluation as candidates for subunit vaccines and/or diagnostic antigens.
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