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Nb-benzoyltryptamine derivatives with relaxant activity in guinea-pig ileum. 2005
Stanley Juan C Gutierrez, and
Fladmir de S Claudino, and
Bagnólia A Da Silva, and
Celso A Câmara, and
Reinaldo N de Almeida, and
Maria de Fátima V de Souza, and
Marcelo S Da Silva, and
Emídio V L Da-Cunha, and
José Maria Barbosa-Filho
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Cx. Postal 5009, 58051-970 João Pessoa, Paraíba, Brazil.
A series of derivatives analogous to Nb-benzoyltryptamine were synthesized by the Schotten-Bauman procedure. The products obtained were: Nb-4-methoxy-benzoyltryptamine, Nb-2,4-dimethoxy-benzoyltryptamine, Nb-3,4-dimethoxy-benzoyltryptamine, Nb-3,4-methylenedioxy-benzoyltryptamine and Nb-3,4,5-trimethoxy-benzoyltryptamine. They were characterized through the usual spectrometric methods (UV, IR, 1H and 13C NMR) and showed non-selective relaxant activity in guinea-pig ileum pre-contracted with acetylcholine, histamine and KCl.
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