-transparent.png){kind=logo}
Peroxynitrite-mediated matrix metalloproteinase-2 activation in human hepatic stellate cells. 2005
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
Clinical Research Center, NHO Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8562, Japan. migita@nmc.hosp.go.jp
To investigate whether hepatic stellate cells (HSCs) alter their expression of MMPs after exposure to nitrogen oxide intermediate (NOI), a human hepatic stellate cell line, LI90 cells, was stimulated with an NO donor, SNAP, or a peroxynitrite donor, SIN-1, and the culture supernatants were analyzed by gelatin zymography or anti-MMPs immunoblot. Although SIN-1 did not enhance the secretions of MMP-1 and 13, SIN-1 induced the NF-kappaB activation, MT1-MMP expression and the secretion of activated MMP-2 in LI90 cells. These results suggest that peroxynitrite may contribute to the remodeling of the extracellular matrix in liver by activating pro-MMP-2.
Related Publications
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
January 1997,
The American journal of pathology,
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
December 2004,
Pathophysiology : the official journal of the International Society for Pathophysiology,
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
July 2019,
International immunopharmacology,
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
April 2020,
Molecular and cellular biochemistry,
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
January 2007,
Journal of hepatology,
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
January 2002,
Cardiovascular research,
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
October 1999,
Hepatology (Baltimore, Md.),
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
September 2002,
Hepatology (Baltimore, Md.),
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
August 2002,
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology,
Kiyoshi Migita, and
Yumi Maeda, and
Seigo Abiru, and
Atsumasa Komori, and
Terufumi Yokoyama, and
Yasushi Takii, and
Minoru Nakamura, and
Hiroshi Yatsuhashi, and
Katsumi Eguchi, and
Hiromi Ishibashi
April 2007,
The Journal of biological chemistry,
