Fifty female drug misusers completed the Eysenck Personality Questionnaire and the Francis scale of attitude towards Christianity on entry to a Christian residential rehabilitation programme. The data confirm the deviant personality profile of drug misusers, who score high on psychoticism and neuroticism and low on extroversion and the lie scale, and demonstrate that the general findings relating religious attitudes to the Eysenckian dimensions of personality among normal populations also hold good among this deviant group, thereby confirming the generalisability of the conclusion that it is psychoticism, rather than neuroticism or extroversion, which is fundamental to religiosity. The practical relevance of these findings is discussed for rehabilitation programmes which include spiritual or religious components.