-transparent.png){kind=logo}
1. The influence of the two antischistosomal drugs (+/-) praziquantel and (+/-) oxamniquine on PGI2 synthesis by the male rat thoracic aorta and day-20 pregnant rat myometrium in vitro was investigated using a rat platelet antiaggregatory bioassay method. 2. Pretreatment of the tissues with praziquantel (64-512 microM) or oxamniquine (36-288 microM) for 30 min at 37 degrees C significantly inhibited basal PGI2 synthesis in a concentration-dependent manner (P less than 0.005, n = 5-6). 3. Both drugs failed to inhibit PGI2 synthesis in presence of exogenous arachidonic acid (AA) (16.6 microM). 4. Furthermore, they did not antagonize AA (4 nmol kg-1)-induced hypotension in urethane-anaesthetized rats. Thus, the drugs seemed to act via inhibition of phospholipase A2 enzyme (PLA2). 5. The highly lipophilic drugs may interact with membrane phospholipids resulting in prevention of interaction between the substrates and the enzyme's active site.
K E el Tahir, and
A M al-Kharji, and
A M Ageel
August 1988,
Prostaglandins, leukotrienes, and essential fatty acids,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
November 1987,
British journal of pharmacology,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
May 1990,
Experientia,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
June 1983,
Journal of the Egyptian Society of Parasitology,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
November 1979,
The Journal of physiology,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
January 1995,
Revista do Instituto de Medicina Tropical de Sao Paulo,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
February 1978,
Prostaglandins,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
January 1990,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
December 1984,
Journal of the Egyptian Society of Parasitology,
K E el Tahir, and
A M al-Kharji, and
A M Ageel
January 1989,
Transactions of the Royal Society of Tropical Medicine and Hygiene,
