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In this study, 11 prepubertal hyperactive boys with tic disorder received placebo and three doses of methylphenidate (0.1, 0.3, and 0.5 mg/kg) for 2 weeks each, under double-blind conditions. Each boy was observed for approximately 20 hours in the school setting (classroom seatwork activities, lunchroom, and playground). Results showed that methylphenidate effectively suppressed hyperactive/disruptive behaviors in the classroom and physical aggression in the lunchroom and on the playground. Methylphenidate also reduced the occurrence of vocal tics in the classroom and the lunchroom. None of the motor tic measures revealed drug effects, but the lowest mean rate of motor tics occurred on the 0.3 mg/kg dose. On an operationally defined minimal effective dose, only one boy experienced motor tic exacerbation.
K D Gadow, and
E E Nolan, and
J Sverd
January 1985,
Psychopharmacology,
K D Gadow, and
E E Nolan, and
J Sverd
October 1989,
Journal of consulting and clinical psychology,
K D Gadow, and
E E Nolan, and
J Sverd
January 1982,
Journal of the American Academy of Child Psychiatry,
K D Gadow, and
E E Nolan, and
J Sverd
March 1984,
Journal of abnormal child psychology,
K D Gadow, and
E E Nolan, and
J Sverd
August 2001,
Journal of abnormal child psychology,
K D Gadow, and
E E Nolan, and
J Sverd
December 1988,
Archives of general psychiatry,
K D Gadow, and
E E Nolan, and
J Sverd
June 1990,
Journal of abnormal child psychology,
K D Gadow, and
E E Nolan, and
J Sverd
July 1974,
Psychophysiology,
K D Gadow, and
E E Nolan, and
J Sverd
April 2020,
Journal of child and adolescent psychopharmacology,
K D Gadow, and
E E Nolan, and
J Sverd
August 2003,
Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie,
