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Cytokines (IL-1 alpha and IL-2) and soluble interleukin 2 receptors (sIL-2r) were evaluated in patients with rheumatoid arthritis (RA) and controls. In RA, serum sIL-2r and IL-1 alpha were increased, and sIL-2r were significantly higher in synovial fluid than in serum. Serum levels of sIL-1r but not IL-1 alpha were increased in patients with acute infections, suggesting additional discriminatory specificity for IL-1 alpha. Both tender and swollen joint scores were higher for patients with RA with serum sIL-2r levels greater than or equal to 700 U/ml. Quantitation of immune mediators may be useful in the clinical assessment of RA in addition to their implication regarding the pathogenesis of the disease.
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
May 1991,
Revue du rhumatisme et des maladies osteo-articulaires,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
January 1996,
Terapevticheskii arkhiv,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
September 1991,
The Journal of rheumatology,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
January 1990,
Revue du rhumatisme et des maladies osteo-articulaires,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
October 1990,
Clinical immunology and immunopathology,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
July 1993,
Clinical immunology and immunopathology,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
December 1990,
Casopis lekaru ceskych,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
January 2007,
La Clinica terapeutica,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
January 1998,
Mediators of inflammation,
R E Wolf, and
W G Brelsford, and
V C Hall, and
S B Adams
January 1992,
Scandinavian journal of rheumatology,
