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The glomerular injuries in 129 cases of IgA nephropathy (IgA-N) were examined ultrastructurally with special reference to the glomerular basement membrane (GBM) deposits and capillary loop abnormalities, and the correlation between these findings and the clinicopathological data was analyzed. The following results were obtained. 1) The degree of daily excretion of urine protein (UP) and creatinine clearance (Ccr) revealed a significant correlation with the degree of mesangial hypercellularities and the frequency of segmental lesions. 2) All sites of GBM deposits, and discontinuity and/or splitting among the GBM abnormalities showed a significant relation to the severity of proliferation and segmental lesions. 3) The GBM deposits, discontinuity and splitting showed a significant relation to the degree of UP and Ccr. We speculate therefore that capillary loop deposits and/or capillary loop discontinuity and splitting could represent histological prognostic factors for an unfavorable outcome in IgA nephropathy.
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
January 1986,
American journal of nephrology,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
May 1987,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
November 2019,
Journal of pathology and translational medicine,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
November 1985,
Nihon Jinzo Gakkai shi,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
June 2002,
Yonsei medical journal,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
May 2012,
Molecular medicine reports,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
January 1988,
The Journal of pathology,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
January 1986,
American journal of nephrology,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
February 1990,
Clinical nephrology,
M Kobayashi, and
A Koyama, and
K Yamagata, and
N Yamaguchi, and
M Narita, and
H Shigematsu
January 1976,
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association,
