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To investigate whether the expression of Topoisomerase II-alpha (TII-alpha) can serve as a prognostic factor in renal cell carcinoma (RCC), histological sections from 27 renal tumors were stained immunohistochemically for TII-alpha expression. The percentage of positive cells in the area of greatest staining was recorded as the TII-alpha index. TII-alpha nuclear staining was positive in all the samples except one. The mean TII-alpha index was 12.5 for grade 1, 44 for grade 2 and 113 for grade 3 tumors. The mean TII-alpha index was 22.3 in tumors which did not recur and 81 for tumors which recurred during the follow-up period. In this study, a higher TII-alpha index correlated with more aggressive tumor behaviour. However, a large cohort of patients should be assessed before drawing definitive conclusions.
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
August 2004,
Analytical and quantitative cytology and histology,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
January 1999,
Anticancer research,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
June 1997,
International journal of oncology,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
April 1999,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
January 1997,
Journal of cancer research and clinical oncology,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
April 1999,
Human pathology,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
January 2001,
Anticancer research,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
January 1997,
Oncology research,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
August 2010,
Nan fang yi ke da xue xue bao = Journal of Southern Medical University,
Yoram Dekel, and
Thomas Frede, and
Valentina Kugel, and
Gad Neumann, and
Jens Rassweiler, and
Rumelia Koren
December 2008,
American journal of clinical pathology,
