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BACKGROUND The protective effect of Ipratropium Bromide (IB) in the methacholine-induced bronchospasm is well known from some time. The objective of the present study was to assess whether a pretreatment with IB may influence the subsequent phase of methacholine-induced bronchospasm relief. METHODS Sixteen patients with bronchial hyper-reactivity (PD20 FEV1 < 200 microg) were randomly assigned to three methacholine challenge tests at a 48 to 72 hours interval apart. In the first test IB was inhaled before the challenge (pre-IB), in the second IB was administered soon after the PD20 FEV1 (post-IB), and in the third no treatment was given (control). RESULTS The pre-IB PD20 FEV1 (695 +/- 587.6 microg) was significantly greater (p < 0.0001) than that of post-IB (82.2 +/- 49.18 microg) and of control (73.9 +/- 41.8 microg). The dose response slope (DRS) (decline percentage of FEV1/cumulative methacholine dose), in pre-IB was greatly lower (p < 0.0001) than that in post-IB and in control. During the bronchospasm relief phase, the increase of FEV1 measured after 5, 10, 15, 30 and 60 minutes from the PD20 FEV1 was significantly greater in post-IB (p < 0.05) compared with the other two conditions. Conversely, the recovery slope (RS) (increase percentage of FEV1 at 60 minutes after PD20 FEV1 x cumulative methacholine dose) was significantly more efficient (p < 0.001) in pre-IB than in post-IB and in control. CONCLUSIONS In conclusion, ipratropium bromide confirmed to have a good protective activity against methacholine-induced bronchospasm; the pre-administration of ipratropium bromide showed also a positive effect on the recovery phase.
B Sposato, and
S Mariotta, and
A Ricci, and
P Bruno, and
C Terzano, and
F Mannino
April 1995,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
B Sposato, and
S Mariotta, and
A Ricci, and
P Bruno, and
C Terzano, and
F Mannino
January 1998,
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B Sposato, and
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C Terzano, and
F Mannino
March 1982,
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B Sposato, and
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B Sposato, and
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B Sposato, and
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C Terzano, and
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B Sposato, and
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C Terzano, and
F Mannino
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B Sposato, and
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C Terzano, and
F Mannino
October 1989,
Chest,
