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Fifteen drug-free schizophrenic male inpatients and 14 normal control subjects were studied. The schizophrenic subjects had a significantly lower ratio of bioassay prolactin to radioimmunoassay prolactin before neuroleptic treatment than they did after treatment. The ratio was lower in the drug-free patients as compared with normal controls. These findings suggest that neuroleptic medications may alter the molecular forms of serum prolactin. The results also suggest that drug-free schizophrenic patients may have a different pattern of prolactin variants than normal subjects and that this difference could be secondary to a disordered tuberoinfundibular dopamine system or long-term effects of neuroleptic drugs.
C A Peabody, and
M D Warner, and
M Griffin, and
N N Boutros, and
I G Worsley, and
H G Friesen
January 1999,
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C A Peabody, and
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M Griffin, and
N N Boutros, and
I G Worsley, and
H G Friesen
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C A Peabody, and
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N N Boutros, and
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H G Friesen
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C A Peabody, and
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C A Peabody, and
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H G Friesen
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C A Peabody, and
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C A Peabody, and
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H G Friesen
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